Aminoglycosides action mechanism

The biochemical mode of action of the aminoglycosides as antibacterials has long been a topic of great interest. Early experiments carried out soon after the introduction of streptomycin suggested a variety of modes of action, but these conclusions were based largely on symptomatic analyses of antibiotic-treated bacterial cultures. One important experiment done in 1948 showed that streptomycin blocks enzyme indnction in susceptible bacteria this was the closest that anyone came to identifying the mechanism of action at the time. 

Cell death pathways may be counteracted by survival signaling cascades in the early stages of intoxication or in cells that are resistant to the toxic actions of the drugs. Signaling via the transcription factor NF-kB may constitute such a homeostatic mechanism in the cochlea. Cells that survived aminoglycoside treatment in a model of chronic ototoxicity were marked by NF-kB activation. ... 

Davis BD (1987) Mechanism of bactericidal action of aminoglycosides. Microbiol Rev 51 341-350 Davis BD, Chen LL, Tai PC (1986) Misread protein creates membrane channels an essential step in the bactericidal action of aminoglycosides. Proc Natl Acad Sci USA 83 6164-6168 Dean N (1995) Yeast glycosylation mutants are sensitive to aminoglycosides. Proc Natl Acad Sci USA 92 1287-1291... 

Mechanism of Action An aminoglycoside antibacterial that irreversibly binds to protein on bacterial ribosomes. Therapeutic Effect Interferes with protein synthesis of susceptible microorganisms. 

Mechanism of Action An aminoglycoside antibacterial that binds to bacterial microorganisms. Therapeutic Effect Interferes with bacterial protein synthesis. Pharmacokinetics Poorly absorbed from the GI tract following PO administration. Protein binding Low. Primarily eliminated unchanged in the feces minimal excretion in urine. Removed by hemodialysis. Half-life 3 hr. 

Mechanism of Action An aminoglycoside that binds directly to the 303 ribosomal subunits causing a faulty peptide sequence to form in the protein chain. Therapeutic Effect Inhibits bacterial protein synthesis. 

The aminoglycosides have probably more than one mechanism of action on bacterial cells. They cause misreading of the RNA code and/or inhibition of the polymerization of amino acids. 

Being chemically similar, the aminoglycosides have many features in common, in particular their mechanism of antibacterial action, a broad antibacterial spectrum,... 

The aminoglycosides have a curare-like action, which can be antagonized by calcium ions and acetylcholinesterase inhibitors (8). The mechanisms include reduced release of acetylcholine prejunctionally and an interaction with the... 

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