Aminoglycoside antibiotics, multiple

Park WKC, Auer M, Jaksche H, Wong CH, Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics use of a polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the HIV RNA Rev responsive elements, J. Am. Chem. Soc., 118 10150-10155, 1996. 

Example determination of a multiple intermittent infusion dosing regimen for an aminoglycoside antibiotic... 

Urinary tract High rates of chronic kidney disease, ototoxicity, and vestibulotoxicity have been reported in patients with cystic fibrosis who require multiple and prolonged courses of aminoglycoside antibiotics [1 ]. The incidence of chronic kidney disease has been reported as up to 42% in patients with cystic fibrosis [2 ]. 

---