Aminoglycoside antibiotics mimetics

Park WKC, Auer M, Jaksche H, Wong CH, Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics use of a polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the HIV RNA Rev responsive elements, J. Am. Chem. Soc., 118 10150-10155, 1996. 

The neamine-derived aldehyde 81 has been prepared and used in combinatorial synthesis of a library of neomycin B mimetic aminoglycoside antibiotics, a strategy for the discovery of new inhibitors for binding to the Rev-responsive element of HIV mRNA [55], The synthesis involves allylation of the selectively protected neamine derivative 80, followed by ozonolysis of the allylic double bond to generate the aldehyde functional group (compounds 80, 81). 

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