Multiple intermittent infusions

Figure 14.2 Multiple intermittent infusion shown in a semilogarithmic plot. Abbreviations as in Fig. 14.1.

Example determination of a multiple intermittent infusion dosing regimen for an aminoglycoside antibiotic... 

Dose to the patient from a multiple intermittent infusion... 

Table 14.3 shows the dose to the patient from two multiple intermittent infusion regimens which differ in the length of the infusion. This table makes use of the equation ... 

Multiple intermittent infusion of a two-comportment drug vancomycin "peak" at 1 h post-infusion... 

The multiple intermittent infusion equation must be modified to reflect the use of the "peak" concentration for vancomycin, as defined above. The modified equation for steady-state peak plasma drug concentration is as follows ... 

For practical purposes, t = 12 h is used. Second, the multiple intermittent infusion rate is calculate using ... 

Calculate a multiple intermittent infusion rate, Q, that will deliver a "peak" steady- state plasma vancomycin concentration of 30mgL , ... 

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