Aminoethanol phosphoric acid

Trade Name Synonyms Actracor M [Georgia-Pacific/Actrachem] MB 450 t[Wemer G. Smith] MEA-dicetearyl phosphate Synonyms Phosphoric acid, bis (Cl 6-C18-alkyl) esters, 2-ami noethanol salt Definition Monoethanolamine salt of a complex mixt. of cetearyl alcohol and phosphoric acid Uses Surfactant in cosmetics MEA-dodecyl benzene sulfonate EINECS/ELINCS 248-024-2 Synonyms Dodecylbenzenesulfonic acid, compd. with 2-aminoethanol (1 1)... 

Sodium aluminum phosphate acidic Phosphoric acid, bis (Cl6-C 18-alkyl) esters, 2-aminoethanol salt. See MEA-dicetearyl phosphate. 

The Mannich-type reaction of amines with formaldehyde and phosphorous acid is a very useful procedure for the preparation of aminomethylenephosphonic acid. Moedritzer and Irani [63] reacted 2-aminoethanol with phosphorous acid and aqueous formaldehyde in the presence of concentrated hydrochloric acid and isolated [(2-hydroxyethyl)imino]dimeth-ylene diphosphonic acid. 

In phosphatides and lysophosphatides, phosphoric acid is further esterified by some hydroxy compounds, namely by choHne (N,N,N-trimethylethanolamine), ethanolamine (2-aminoethanol), L-serine, myo-inositol and glycerol. 

Phosphates of pharmaceutical interest are often monoesters (Sect. 9.3), and the enzymes that are able to hydrolyze them include alkaline and acid phosphatases. Alkaline phosphatase (alkaline phosphomonoesterase, EC 3.1.3.1) is a nonspecific esterase of phosphoric monoesters with an optimal pH for catalysis of ca. 8 [140], In the presence of a phosphate acceptor such as 2-aminoethanol, the enzyme also catalyzes a transphosphorylation reaction involving transfer of the phosphoryl group to the alcohol. Alkaline phosphatase is bound extracellularly to membranes and is widely distributed, in particular in the pancreas, liver, bile, placenta, and osteoplasts. Its specific functions in mammals remain poorly understood, but it seems to play an important role in modulation by osteoplasts of bone mineralization. 

---