7-aminocephalosporic acid

A recent example of an attempt to determine whether using a renewable bio-logicaUy-based process for making a particular product exhibits a better environmental profile in comparison to using a synthetic pathway is the comparison of two different processes for the manufacture of the pharmaceutical intermediate 7-aminocephalosporic acid (7-ACA) as a case study [33]. The methodology used for the assessment integrates environment, health, safety, and life cycle aspects... 

Cephalosporins are derived from cepham. Cephalosporin C, a metabolite of Cephalosporium acremonium, was isolated by Newton and Abraham in 1955. Its structure was established in 1961 by chemical methods and X-ray diffraction. It is an acid amide derived from (i )-a-aminoadipic acid and 7-aminocephalosporic acid. The latter is (6i ,7i )-3-acetoxymethyl-7-amino-8-oxoceph-3-em-4-carboxylic acid. 

Cefatrizine is a second-generation semisynthetic cephalosporin antibiotic introducedin 1991 [134]. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cefatrizine is used to treat a large variety of bacterial infections, such as respiratory tract, ear, skin, and urinary tract infections (Scheme 2.13). 

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