2-Aminocarbonyl-l-

Heating 2-(arylaminothiocarbonyl)-T(2-hydroxyethyl)-l,2,3,4-tetrahydroisoquinolines in EtOH in the presence of HC1 afforded 4-arylimino-l,6,7,llb-tetrahydro-2/7,477-[l,3]thiazino[4,3-tf]isoquinolines <2001ARK33>. 1,3,4,6,7,11b-Hexahydro-2/7-pyrimido[6,l-+]isoquinoline-2,4-diones were obtained by the cyclization of 2-(2-aminocarbonyl-l,2,3,4-tetrahydroisoquinolin-l-yl)acetates on the action of a base <2004MOL694>. 

Beim Erhitzen mit 20%iger Salzsaure bzw. Ammoniumhydrogensulfid reagieren 2,5-Diamino-1,3,4-oxadiazole zu l,2-Bis-[amino-carbonyl]- bzw. 2-Aminocarbonyl-l-(amino-thiocarbonyl)-hydrazinen276. 

Aziridin 2-Aminocarbonyl-l-[2-cyan-2-ethoxycarbonyl-l-(5-nitro-2-furyl)-ethenyl]- E16c. 555 (NH - N-R)... 

Oxidative cyclization of 1 -[(2 -aminocarbonyl)phenyl]piperidine and its 4 -substituted derivatives with Hg(OAc)2-EDTA reagent afforded 1,2,3,4-tet-rahydro-6//-pyrido[2,l-Z)]quinazolin-6-one and its 3-substituted derivatives in 36-82% yields (99ZN(B)1577). Similarly, ( )-2-(piperidin-2-yl)benzal-doximes gave 2,3,4,4u-tetrahydro-l//-pyrido[l,2-u]quinazolin-5-oxide and... 

In wafir. Athanol mit Acetatpuffer erhalt man dagegen aus 2-Aminocarbonyl- bzw. in 1 n Salzsaure aus 2-(N-Methyl-anilinocarbonyl)-l,3-thiazol 2-Hydroxymethyl-l,3-thiazol (59 bzw. 67% d.Th.). 2-Anilinomethyl-1,3-thiaz.ol (50% d.Th.) wird aus dem Anilid in 0,8 n Salzsaure bei —0.7 V gebildet7. 

Bei —0,15 bis -0,4 V entsteht 3-Hydroxy-(naphtho-[ ,2-c]-oxazol) bzw. I-Hydr-oxy- (naphtho-[2,l-c]-l,2-oxazol) aus l-Nitro-2-aminocarbonyl- bzw. 2-Nitro-l-amino-carbonyl-naphthalin5 ... 

Analog reagieren 3-Nitro-2-aminocarbonyl- und 8-Nitro-l-aminocarbonyl (bzw. carboxy)-naphthalin5 zum 1 -Hydroxy-(naphtho-[2,3-c -1,2-oxazol) bzw. 8-Amino-naphthalin-1 -carbonsaure-lactam ... 

N-Diphenylmethylen- 374 N-Diphenylmethylen-O-aminocarbonyl- 612 N-[l,3-Diphenyl-propyl-(2) - 374 N-[l,3-Diphenyl-propyliden-(2)]- 374, 377, 380 N-(4-Halogen-phenyI)- 683 N-Heptyl- 375 N-Heptyl-N-acetyl- 376 N-Heptyliden- 375 N-Hcptyliden-O-acetyl- 376 0-(2-Hydroxy-athyl)-N-athoxycarbonyl- 133 N-(4-Hydroxy-phenyl)- 683 0-(2-Hydroxy-l-phenyl-athyI)-N-athoxycarbonyI-aus 0-(ci-AthoxycarbonyI-benzyl)-N-athoxycar-bonyl-hydroxylamin und Lithiumalanat 133 N-Isopropyl- 682 N-Isopropylidcn- 613 N-Methyl- 133, 682 O-Methyl-N-bcnzyliden- 377 O-Methyl-N-benzyliden- 375 0-Methyl-N-(4-chlor-benzyl)- 375 0-Methyl-N-(4-chlor-benzyliden)- 375 N-Methy -N,0-diacetyI- 682 N-(4-Methyl-phenyl)- 683 0-McthyI-N-( 1 -phenyl-athyliden)- 375 N-(4-Methylthio-phenyl)- 684 N-(4-Nitro-benzyl)- 374 N-[4-Nitro-benzyliden - 374, 377 N-(2-Nitro-phenyl)- 562 N-(4-Nitro-phenyl)- 682 N-Nitroso-N-cyclohexyl- 697 N-Octyl- 374 N-Octyl-(2)-N-acetyl- 376 N-Octyliden- 374 N-0ctyliden-(2)-0-acctyl- 376 N-(Pentafluor-phenyl)-0,N-diacetyl- 697 N-Phenyl- 474, 481, 682, 783 N-Phenylacetyl-O-benzoyl- 265 N-(l-Phenyl-athyl)- 374 N-(l-Phenyl-athyl)-N-acetyl- 376 N-(l-Phenyl-athyliden)-374, 613 N-( l-Phenyl-athyliden)-0-acetyl- 376 N-[ 1 -Phenyl-buten-( 1 )-yl-(3)-iden]- 582 N-f4-Phenyl-butyl-(2)-iden]- 581 N-Phcnyl-N,0-diacetyl- 682 N-(4-Phenylthio-phenyl)- 684 N-Propyl-N-cyclohexyl- 376 N-Propyl-N-isopropyl- 376 O-Sulfonyl- 481 N-(4-Sulfonyl-phenyI)- 683 N-(2-Vinyl-phenyl)- 698... 

Ainino t-(methylamino-hydroxy-methyl)- 597 1-Anilinocarbonyl- 136 l-Benzyl-2-aminocarbonyl- 600... 

CN 2-[2-[(aminocarbonyl)oxy]-l-methoxyethyl]-3,6-bis(l-aziridinyl)-5-methyl-2,5-cyclohcxadiene-l,4-dione... 

CN [25-[2a,3a(Z)]]-[[[2-[[2-[[(aminocarbonyl)oxy]methyl]-4-oxo-l-sulfo-3-azetidinyl]amino]-l-(2-amino-4-thiazolyl)-2-oxoethylidene]amino]oxy]acetic acid... 

CN [6R-[6a,7P(R )]]-4-(aminocarbonyl)-l-[[2-carboxy-8-oxo-7-[(phenylsulfoacetyl)amino]-5-thia-l-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium hydroxide inner salt... 

CN stereoisomer of 3,6-diamino-Al-[6-[[(aminocarbonyl)amino]methylene]-3-(2-amino-l,4,5,6-tetrahydro-6-hydroxy-4-pyrimidinyl)-9, 12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaazacyclohexadec-15-y l]hexanamide... 

CiiHijNO, 3SS4J-4J-7) see Carboquone 2-(2-aminocarbonyloxy-l-methoxyethyl)-S-methyl-hydroquinone dimethyl ether (CjjHiijNOj 38843-63-9) see Carboquone [6U-[6a,7a,7(iJ )])-3-[[(aminocarbonyl)oxyJmethyl]-7-[[5-carboxy-S-[[(4-methylphenyl)sulfonyl]amino]-l-oxo-pentyl]amino]-7-methoxy-8-oxo-5-thia-l-azabicy-clo[4.2.01oct-2-ene-2-carboxylic acid compd. with A-cyclohexylcyclohexanamine (1 1)... 

Other interesting examples of these amino-exchange reactions are the conversion of 3-aminocarbonyl-4-R-l-(2,4-dinitrophenyl)pyridinium salt (2) into 3-aminocarbonyl-4-R-l-cbutylpyridinium salt by Cbutylamine (82RTC342) and the preparation of l-(pentadeuteriophenyl)-3-amino-carbonyl-4-deuteriopyridinium salt from 3-aminocarbonyl-l-(2,4-dinitro-phenyl)-4-deuteriopyridinium salt (2, R = D) with pentadeuterioaniline (84T433) (Scheme IIL2). 

In the pyridine V-oxide series a C-N exchange rearrangement was also observed when 3-aminocarbonyl-l-methoxypyridinium salt (131) reacts with ammonia or alkali, 3-methoxyiminomethylpyridin-2(l//)-one (132) being obtained (74T4055). This conversion takes place via the ANRORC pathway the ring opening occurs between N-1 and C-6 after initial addition of the hydroxide ion at C-6 (Scheme IV.50). 

Bleomycin Bleomycin is a stereoisomer of 6-amino-A-[[2-[[4-[[l-[[[2-[4-(aminocar-bonyl)[2,4i-bintiazol]-2i-yl]ethyl]amino]carbonyl]-2-hydroxypropylamino-2-hydroxy-l,3-dimethyl-4-oxobutyl]amino-l-[[2-0-[3-0-(aminocarbonyl)-a-D-... 

Carbonsaure-nitrile konnen mit starken Alkylierungsmitteln [z. B. Trifluor-methansulfonsaure-methylester222,223, Eisen(IIl)-chlorid/2-Chlor-propan224] zu den entsprechenden Nitrilium-Sal-zen umgesetzt werden. Aus N-Methyl-acetnitrilium-trifluormethansulfonat und Diamino-ma-leinsaure-dinitril erhalt man je nach Reaktionsbedingungen 5-Amino-4-aminocarbonyl-l,2-dimethyl-, 5-Amino-4-cyan-l,2-dimethyl- oder 5-Amino-4-(cyan-imino-methyl)-l,2-dimethyl-imid-azol222 223. 

Mit N(a)-tert.-Butyloxycarbonyl-2-diazo-L-histidin-methylester gelingt auch die Isolierung der 2-Diazo-Verbindung eines Histidin-Derivates1069. 5-Aminocarbonyl-4-diazo-imidazol reagiert mit Hydrazin zu 5(4)-Aminocarbonyl-4(5)-azido-imidazoli06 1069. 

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