1- Amino-3,5,7-trimethyl

Benzyl-methyl-amin<>)-tetrafluor-phosphoranH3 In einem GlasgefaB werden bei -196° 7,6 g (0,06 mol) Phosphor(V)-fluorid zu 11,6 g (0,06 mol) (Benzyl-methyl-amino)-trimethyl-silan kondensiert. Das verschlos-sene GcfaB wird 2 Tage bei -78°gehalten. Nach Abziehen der fliichtigen Bestandteile wird das Produkt i. Vak. destilliert Ausbeute 9,8 g (72%) Sdp. 78780 Torr (10,67 kPa). 

Benzyl-niethyl-aininol-phenyl-trifluor-pliosplmraii 9 9,6 g (50 mmol) (Benzyl-methyl-amino)-trimethyl-siJan werden bei 50° tropfenweise unter Riihren zu 9,2 g (50 mmol) Phenyl-tetrafluor-phosphoran gegeben. Nach 1 Stde. Erhitzen auf 90° wird der Kolbenriickstand i. Vak. destilliert Ausbeute 12,9 g (96%) Sdp. 11675 Torr (6,67 Pa). 

Germanium (tert.-Butyl-methyl-amino)-trimethyl- XIII/6, 142... 

Blei [(Di-tert.-butyl-phosphano)-amino]-trimethyl- XIII/7, 133... 

CyHiiBNiSi bis(dimethyl-amino)-(trimethyl-silyl)-borane 6917-95-9... 

The inhibitor mixture was tested based on amino-trimethyl phosphonic acid (ATMP) in combination with zinc chloride and small amounts of polyphosphates (Gonzalez et al.,... 

Dioxopiperazines are amongst the most ubiquitous of natural products (75FOR(32)57) and they are formally derived by the cyclodimerization of a-amino acids (69CCC4000) or their esters. A number of methods are available for their oxidation to the corresponding pyrazines. Treatment of 2,5-dioxopiperazines with triethyl- or trimethyl-oxonium fluorobor-ate followed by oxidation with DDQ, chloranil or iodine results in pyrazine formation, usually in high yields (Scheme 63) (72JCS(P1)2494). 

N-Amination of indazole affords a mixture of 60% (271) and 40% (272), which compares with the 55 45 ratio obtained in methylation (Section 4.04.2.1.3(viii)). A camphopyrazole derivative (a mixture of tautomers 275 and 276) when treated with hydroxylamine O-sulfonic acid yields exclusively the (4S,7i )-4,7-methano-2-amino-7,8,8-trimethyl-4,5,6,7-tetrahydro-2H-indazole (277) (79YZ699). 

Pteridine, 2-amino-4,6,7-trimethyl-basicity, 3, 267 Pteridine, 2,2 -anhydro-nucleosides, structure, 3, 283 Pteridine, 2,5 -anhydro-nucleosides structure, 3, 283 Pteridine, 6-aryl-synthesis, 3, 316 Pteridine, 7-aryl-synthesis, 3, 314... 

Pyrylium salts, 3-acetyl-2,4,6-trimethyl-crystallography, 3, 625 Pyrylium salts, 3-alkoxymethyl-synthesis, 3, 865 Pyrylium salts, alkyl-deprotonation, 2, 51 reactions, 2, 50 Pyrylium salts, 2-amino-reactions, 2, 55 Pyrylium salts, 4-amino-deprotonation, 2, 55... 

The intermediate formation of iminium salts is postulated in the reduction of (x-amino ketones by the Clemmensen method, occurring with concomitant ring enlargement or contraction (244-246). Reduction of l,2,2-trimethyl-3-piperidone (154) in this manner gave l-methyl-2-iso-propylpyrrolidine (155). 

Dioxo-2, 4, 5 -trimethylcyclohexa-l, 4 -diene)-3,3-dimetbylpropi-onamide (Q). The application of this well-known acid [3-(3, 6 -dioxo-2, 4, 5 -trimethylcyclohexa-l, 4 -diene)-3,3-dimethylpropionic acid] to protection of the amino function for peptide synthesis has been examined. Reduction of the quinone with sodium dithionite causes rapid trimethyl lock -facilitated ring closure with release of the amine. 

Interesting results were also obtained on treatment of 2-amino-4,6,6-trimethyl-dihydropyrimidine 50 and 2,4,6,6-tetramethyldihydropyrimidine 51 with CD3OD in the absence of a base (91TL2057). It was shown that, under these conditions, the 4-methyl protons of 50, the 2,4-dimethyl protons of 51, and H(5) in 50 and 51 undergo H-D exchange. The suggested mechanism involves annular (1,4-dihydro 4,5-dihydro) as well as substituent tautomeric equilibria, as shown in Scheme 20 for H-D exchange in 50. 

A solution of 25.8 g. (0.20 mole) of 4-amino-2,2,4-trimethyl-pentane (ierf-octylamine) (Note 1) in 500 ml. of C.P. acetone is placed in a 1-1. three-necked flask equipped with a Tru-Bore stirrer and a thermometer and is diluted with a solution of 30 g. of magnesium sulfate (Note 2) in 125 ml. of water. Potassium permanganate (190 g., 1.20 moles) is added to the well-stirred reaction mixture in small portions over a period of about 30 minutes (Note 3). During the addition the temperature of the mixture is maintained at 25-30° (Note 4), and the mixture is stirred for an additional 48 hours at this same temperature (Note 5). The reaction mixture is stirred under water-aspirator vacuum at an internal temperature of about 30° until most of the acetone is removed (Note 6). The resulting viscous mixture is steam-distilled approximately 500 ml. of water and a pale-blue organic layer are collected. The distillate is extracted with pentane, the extract is dried over anhydrous sodium sulfate, and the pentane is removed by distillation at atmospheric pressure. The residue is distilled through a column (Note 7) at reduced pressure to give 22-26 g. (69-82%) of colorless 4-nitro-2,2,4-trimethylpentane, b.p. 53-5473 mm., < 1.4314, m.p. 23.5-23.7°. 

Methylamino-1,4-benzenediamine hydrochloride (173) gave 7-amino-l,2,3-trimethylquinoxalinium chloride (174) (Ac2, no details) and thence 2,3,4-trimethyl-6(477)-quinoxalinimine (175) (Na2C03, no details). 

The steps in the subsequent utilization of muscle LCFAs may be summarized as follows. The free fatty acids, liberated from triglycerides by a neutral triglyceride lipase, are activated to form acyl CoAs by the mediation of LCFAcyl-CoA synthetase which is situated on the outer mitochondrial membrane. The next step involves carnitine palmitoyl transferase I (CPT I, see Figure 9) which is also located on the outer mitochondrial membrane and catalyzes the transfer of LCFAcyl residues from CoA to carnitine (y-trimethyl-amino-P-hydroxybutyrate). LCFAcyl... 

---