2-Amino-2-methyl-l-propanol

ALKANOLAMNES - ALKANOLAMINESFROMNITHOALCOHOLS] (Vol2) 2-amino-2-methyl-l-propanol... 

Nltropropane. As much as 9100 t of 2-nitropropane once were consumed for use in coatings annually. Concern about toxicity and a general movement to low volatile organic compound (VOC) coatings have resulted in almost the complete disappearance of this use for 2-nitropropane. However, derivatives such as 2-meth5l-2-nitro-l-propanol (used in tire cord adhesive) and 2-amino-2-methyl-l-propanol (a pigment dispersant and buffer), have served as an outlet for 2-nitropropane production. 

Oxidation of the hydroxyl group, after protection of the amine group by ben2oylation, gives amino acids (7), eg, oxidation of 2-amino-2-methyl-l-propanol to 2-methylalanine [62-57-7] (CH )2CNH2COOH. 

Various amines find application for pH control. The most commonly used are ammonia, morpholine, cyclohexylamine, and, more recently AMP (2-amino-2-methyl-l-propanol). The amount of each needed to produce a given pH depends upon the basicity constant, and values of this are given in Table 17.4. The volatility also influences their utility and their selection for any particular application. Like other substances, amines tend towards equilibrium concentrations in each phase of the steam/water mixture, the equilibrium being temperature dependent. Values of the distribution coefficient, Kp, are also given in Table 17.4. These factors need to be taken into account when estimating the pH attainable at any given point in a circuit so as to provide appropriate protection for each location. 

ABMA ACH AGR AMP AMP American Boiler Manufacturers Association aluminum chlorhydrate advanced gas-cooled reactor aminotri-(methylenephosphonic acid) 2-amino-2-methyl-l-propanol, AKA isobutanolamine... 

The most widely used amine is monoethanolamine (MEA), which is considered as a benchmark solvent because of its high cyclic capacity, significant absorption-stripping kinetic rates at low C02 concentration and high solubility in water. Some other amine-based solvents such as diethanolamine (DEA), triethanolamine (TEA), diglycolamine (DGA), N-methyldiethanol-amine (MDEA), piperazine (PZ), 2-amino-2-methyl-l-propanol (AMP) and N-(2-aminoeth-yl)piperazine (AEP) have also traditionally been utilised. 

Recent developments for reactive C02 sorbents include sterically hindered amines such as 2-amino-2-methyl-l-propanol (AMP) and 1,8-p-methanediamine (MDA) and 2-piperidine ethanol (PE), which are claimed to have good reversible C02 capacity (Veawab et al., 1998) and low-temperature molten salts called ionic liquids (Bates et al., 2002). Ionic liquids are attractive due to their negligible vapor pressure up to their decomposition at... 

Dimethyl-2-oxazoline is commercially available from Columbia Organic Chemicals, 912 Drake Street, Columbia, South Carolina, or may be prepared as follows. In a 250-ml., three-necked flask is placed 89.14 g. (1.0 mole) of 2-amino-2-methyl-l-propanol, and the flask is cooled in an ice bath. The amine is carefully neutralized with 52.3 g. (1.0 mole) of 90.6% formic acid over a 1-hour period. A magnetic stirring bar is added, the flask is fitted with a short path distillation head, and the reaction mixture is placed in a silicon oil bath which is rapidly heated to 220-250°. The azeotropic mixture of water and oxazoline distills over a period of 2-4 hours and is collected in an ioe-cooled flask containing ether. The aqueous layer is separated, saturated with sodium chloride, and extracted with three 50-ml. portions of ether. The combined ethereal extracts are dried over potassium carbonate, filtered to remove the drying agent, and the ether is removed at 35-40° at atmospheric pressure. The 4,4-dimethyl-2-oxazoline is collected as the temperature rises above 85°. The yield is 56.7-62.7 g. (57—63%) of a colorless mobile liquid, b.p. 99-100° (758 mm. Hg). 

Bilirubin is eliminated by dializing the incubated /Miitrophenolate ion (at pH 10.5, and maintaining at 38°C for 30 minutes) into 2-amino-2-methyl-l-propanol, without carrying out the blank determination stated... 

The 2-amino-2-methyl-l-propanol, m.p. 25-29°, N.E. 88.5-99.0, was obtained from the Commercial Solvents Corporation... 

Amino-2-methyl-l-propanol [124-68-5] NI 89.4, m 31°, b 164-166 /760mm, d 0.935. Purified by distn and fractional freezing. 

Does the 13C NMR spectrum shown in Figure 22.10 correspond to that of l-amino-2-methyl-2-propanol or to 2-amino-2-methyl-l-propanol Could this compound be prepared by reaction of... 

AP isoenzymes can cleave associated phosphomonoester groups from a wide variety of substrates. The exact biological function of these enzymes is still uncertain. They can behave in vivo in their classic phosphohydrolase role at alkaline pH, but at neutral pH AP isoenzymes can act as phosphotransferases. In this sense, suitable phosphate acceptor molecules can be utilized in solution to increase the reaction rates of AP on selected substrates. Typical phosphate acceptor additives include diethanolamine, Tris, and 2-amino-2-methyl-l-propanol. The presence of these additives in substrate buffers can dramatically increase the sensitivity of AP ELISA determinations, even when the substrate reaction is done in alkaline conditions. 

In one isomer the lowest field signal is a quaternary carbon in the other it is a CH2 group. The spectrum shown in Figure 22.10 shows the lowest field signal as a CH2 group. The compound is therefore 2-amino-2-methyl-l-propanol, (CH3)2CCH2OII. 

Equimolecular proportions of theophylline and 2-amino-2-methyl-l-propanol are dissolved in water and the water is evaporated until crystallization is almost complete. The crystals are filtered off and dried. The product has a melting point of 254-256°C, softening at 245°C. It has a water solubility of about 55%. It may be compounded in the form of tablets, for oral administration, or may be prepared in solution for distribution in ampoules. For the manufacture of solutions for packaging in ampoules, it is more convenient to simply dissolve the theophylline and the butanolamine in water, without going through the intermediate step of separating the crystalline salt. 

A. 2,2-Dimethylethylenimine. A cold mixture of 110 g. (60 ml., 1.06 moles) of concentrated sulfuric acid and 200 ml. of water is added in portions, with shaking, to a solution of 100 g. (107 ml., 1.12 moles) of 2-amino-2-methyl-l-propanol in 200 ml. of water contained in a 1-1. round-bottomed flask (Note 1). The flask is fitted with a thermometer extending into the liquid and a short still head carrying a downward condenser. 

The 2-amino-2-methyl-l-propanol used was the Practical grade obtained from the Eastman Kodak Company. This iminoalcohol can also be secured from the Commercial Solvents ( orporation. 

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