Amino-cyclohexyl-phenyl

Hohe optische Ausbeuten an 2-Amino-alkanen [z.B. (S)-2-Amino-butan, (S)-l-Amino-1-cyclohexyl-ethan] und Amino-ary 1-alkanen [z.B. (S)-i- und (S)-2-Amino-1-phenyl-propan] erhalt man auch bei der Reduktion der entsprechenden Ketoxime mit einem aus Lithium-alanat und 3-0-Cyclohexylmethyl-l,2-0-cyclohexyliden-a-D-glucofuranose ge-bildeten Komplex in Ether3. 

A series of 2-amino-3-guanidinocarbonylpyrazines has been prepared from the corresponding 2-amino-3-alkoxycaibonylpyrazine when refluxed with guanidine or with a guanidine salt and sodium alkoxide in the alcohol. Some pyrazine esters that have been converted with guanidine to guanidinocarbonyl compounds by the above method are as follows 2-amino-3-methoxycarbonyl (787, 802) 2-amino-3-methoxycarbonyl-5-methyl(ethyl, cyclopropyl, cyclohexyl, phenyl, and... 

Methylamino-1 -( 2-chlor-phenoxy)- 451 2-Methyl- l-(2-amino-cyclohexyl)- l-furyl-(2)- 441 2-Methylamino- l-(N-cyclopropyl-benzylamino)- 452 2-Methylamino- l-(2,4-dichlor-phenoxy)- 451 2-Methylamino- l-methylimino-2-methyl- 1-phenyl-233... 

Isocyanide, benzyl, 55, 98 Isocyanide, butyl-, 55, 98 Isocyanide, cyclohexyl-, 55, 98 ISOCYANIDE, 1,1-dimethylethyl- [Isocy-amde, tert-butyl-], 55,96 Isocyanide, dodecanyl- 55,98 Isocyanide, ethyl- 55,98 Isocyanide, methyl-, 55, 98 Isocyanide, phenyl-, 55, 98 1//Isoindole 1,3(2//) dione, 2 amino [Phthahmidc, N-amino-], 55, 115 1//-ISOINDOLE-1,3(2//)-DIONE, trans-( )-2-(2,3-diphenyl-l-aziridinvl)-[Azindine, frans-2,3-diphenyl-l-phthalimido-], 55, 115 ISOXAZOLE, 3-(4-chlorophenyl)-5-(4-methoxy phenyl)-, 55, 39 Isoxazole 5-(4-chlorophenyl)-3-(4-meth-oxyphenyl)-, 55, 42... 

CN ( )-A/-cyclohexyl-/V -[4-[3-[(l,l-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]urea... 

In addition, dimer-type black developing fluoran compounds such as 2,2-bis(4-[6 -(/V-cyclohexyl-/V-methylamino)-3 -methylfluoran-2 -yl-amino]phenyl propane (59)60 are also proposed. Fluoran 59 has much lower solubility in organic solvents to improve image stability to plasticizer for use in thermosensitive recording label paper. 

Treatment of 2 -anilinofluorans with ketones such as acetone or 2-butanone in hydrochloric acid in the presence of iron(III) chloride gives 4,4 -alkylidenebis(A-fluoran-2-ylaniline)s. Thus, 2 -anilino-6 -(A-cyclohexyl-/V-methylainino)-3 -methylfluoran, (86) is treated with acetone in hydrochloric acid in the presence of iron(III) chloride to give 2,2-bis(4-[6 -(N-cy c 1 o hexyl-Ar-methy 1 amino)-3 -methylfluoran-2 -ylamino]phenyl (propane (87)60 (Eq. 9). 

In a related series of 1,2,4-trisubstituted anthraquinone compounds, the effectiveness of various polar and nonpolar substituents to improve on the low heat fastness of 2-amino-1,4-dihydroxyanthraquinone (3.184 R = H) was examined (Table 3.50). Short-chain alkyl groups (methyl, ethyl) and even the pyranylmethyl ether are relatively ineffective but hydroxyalkyl, cyclohexyl, benzyl and morpholinylethyl groups show moderate increases. Further improvement is given by phenyl, pyridylmethyl and morpholinylpropyl. Outstandingly effective, however, are the benzothiazolyl, dodecylphenyl and fluoro-methylphenyl groupings. 

To verify such a steric effect a quantitative structure-property relationship study (QSPR) on a series of distinct solute-selector pairs, namely various DNB-amino acid/quinine carbamate CSPpairs with different carbamate residues (Rso) and distinct amino acid residues (Rsa), has been set up [59], To provide a quantitative measure of the effect of the steric bulkiness on the separation factors within this solute-selector series, a-values were correlated by multiple linear and nonlinear regression analysis with the Taft s steric parameter Es that represents a quantitative estimation of the steric bulkiness of a substituent (Note s,sa indicates the independent variable describing the bulkiness of the amino acid residue and i s.so that of the carbamate residue). For example, the steric bulkiness increases in the order methyl < ethyl < n-propyl < n-butyl < i-propyl < cyclohexyl < -butyl < iec.-butyl < t-butyl < 1-adamantyl < phenyl < trityl and simultaneously, the s drops from -1.24 to -6.03. In other words, the smaller the Es, the more bulky is the substituent. The obtained QSPR equation reads as follows ... 

A number of nonnatural amino acids were resolved into individual enantiomers on 0-9-(2,6-diisopropylphenylcarbamoyl)quinine-based CSPby Peter and coworkers [48,90,113,114] after derivatization with Sanger s reagent, chloroformates (DNZ-Cl, FMOC-Cl, Z-Cl), Boc-anhydride, or acyl chlorides (DNB-Cl, Ac-Cl, Bz-Cl). For example, the four stereoisomers of P-methylphenylalanine, P-methyltyrosine, P-methyltryptophan, and P-methyl-l,2,3,4-tetrahydroisoquinoline-3-carboxylic acid could be conveniently resolved as various A-derivatives [113]. The applicability spectrum of cinchonan carbamate CSPs comprises also P-amino carboxylic acid derivatives, which were, for example, investigated by Peter et al. [114]. A common trend in terms of elution order of DNP-derivatized P-amino acids was obeyed in the latter study On the utilized quinine carbamate-based CSP, the elution order was S before R for 2-aminobutyric acid, while it was R before S for the 3-amino acids having branched R substituents such as wo-butyl, iec-butyl, tert-butyl, cyclohexyl, or phenyl residues. 

Cyclization of A-acyl-oc-amino acids under acidic reaction conditions is sometimes problematic due to the difficulty in separation of the desired oxazolone from by-products while avoiding decomposition of the reactive oxazolone. This finding is particularly true in the case of 2-phenyl-5(47i)-oxazolone, an interesting compound that is a very useful intermediate to prepare a variety of novel products. The use of carbodiimides as dehydrating agents has been described as a means to improve the results. In particular, treatment of an A-acyl-a-amino acid with A-cyclohexyl-A -2-(A-methylmorpholinio)ethylcarbodiimide p-toluensulfo-nate (Scheme 7.25) is especially useful as a general synthesis of the desired saturated 5(47i)-oxazolones 101 in excellent yields.This same carbodiimide was used to study the kinetics of the formation of saturated 5(47i)-oxazolones from N-protected dipeptides... 

Indirect support for this hypothesis has now been obtained. Phenyla-tion of 3-cyclohexyl pyridine with phenyllithium gave a 2,3-/2,5-isomer ratio of 65 35.2460 The cyclohexyl radical is expected to be at least as bulky as a phenyl radical. The exclusive formation of the 2,3-isomer in the reaction of phenyllithium both with 3-amino- and 3-methoxy-pyridine has been attributed to the formation of a complex such as 111 between the lone-pair of electrons on the 3-substituent and the lithium atom, in which the phenyl group would be suitably... 

Amino-6-cyclohexyl-2-pyrazinecarboxamide 3-Amino-5-cyclohexyl-2-pyrazinecarboxylic acid 3-Amino-6-cyclohexyl-2-pyrazinecarboxylic acid 3-Amino-/V-cyclopentyl-2-pyrazinecarboxamide 3-Amino-6-cyclopropyl-2-pyrazinecarbonitrile 3-Amino-6-cyclopropyl-2-pyrazinecarboxamide 3-Amino-6-cyclopropyl-2-pyrazinecarboxylic acid 3-Amino-5,6-dichloro-2-pyrazinecarbaldehyde 3-Amino-5,6-dichloro-2-pyrazinecarbonitrile 3-Amino-5,6-dichloro-2-pyrazinecarboxamide 3-Aniino-5,6-dichloro-2-pyrazinecarboxylic add 3-Amino-6-diethylaminomethyl-2-pyrazinecarbonitrile 3-Amino-5-diethylamino-2,6-pyrazinedicarbonitrile 5-Amino-3-dimethylamino-6-nitro-2-pyrazinecarbonitrile 3-Amino-5-dimethylamino-6-phenyl-2-pyrazinecarbohydrazide... 

Methyl 6-amino-5-cyano-3-methyl-2-pyrazinecarboxylate 1-oxide Methyl 3-amino-5-cyclohexyl-2-pyrazinecarboxylate Methyl 3-amino-6-cyclohexyl-2-pyrazinecarboxylate Methyl 3-amino-6-cyclopropyl-2-pyrazinecarboxylate Methyl 3-amino-5,6-dichloro-2-pyrazinecarboxylate Methyl 3-amino-5-dimethylamino-6-methyl-2-pyrazinecarboxylate Methyl 3-amino-5-dimethylamino-6-phenyl-2-pyrazinecarboxylate Methyl 3-amino-5-dimethylamino-2-pyrazinecarboxylate Methyl 3-amino-5,6-dimethyl-2-pyrazinecarboxylate 2-Methylamino-3,5-diphenylpyrazine 2-Methylamino-3,6-diphenylpyrazine... 

Addition of cyclohexyl isocyanide to 4-amino-l-chroma-l,3-dienes ( )-96b-e provides a mild and regiospecific access to l,4-diamino-2-ethoxy naphthalenes 104 [l-NHc-QHn 4-NRR1 = NMe2, (S)-2-hydroxymethyl-pyrrolidinyl, (lf ,25)-2-methylamino-l-phenyl-l-propanol, N-f-BuMe] in... 

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