2-Amino- -chlorid

An efficient sequential reaction process was developed from y-amino chlorides 42 with propargylate 41 (Scheme 16). In the proposed mechanism, after the alkylation of the nitrogen atom, a subsequent cyclization by the same nucleophilic center induced the formation of intermediate 43, which cyclized to afford the indolizidine 44 <20010L3927, 20050L705>. This synthetic approach found application in the synthesis of indolizidine 223A. 

Phosphonium Chlor-tris-[dimethyl-amino]- (chlorid) El, 531 (R3P + Cl2)... 

The chloromethyl imines lOa-lOi were employed as representatives of derivatives with a potentially reactive group in the side chain. Their reduction afforded the corresponding amines in >90% ee (Table 4.6, entries 1 9). The resulting amino chlorides were then cyclized to the corresponding aziridines on treatment with t BuO K with retention of the stereochemical integrity [ 12d]. It is pertinent to note that the preparation ofthe sensitive chloro imines lOa-lOi from the a chloro ketones was not entirely free of problems while the electron neutral and electron poor imines lOa-lOc were synthesized and isolated as individual substances, their electron rich counterparts lOg and lOh could not be obtained as pure compounds, since the reaction did not proceed to completion. Therefore, in the latter instances, the imines were generated in situ [12d]. 

The isomeric o-aminophenylmercuric acetate is difficult to separate from the larger amount of the p- compound which would separate with it if the filtrate from the initial crop of the p- acetate were allowed to stand. Dimroth found, however, that there was a considerable difference in the solubilities of the chlorides, so the filtrate is treated with an excess of sodium chloride solution, precipitating p-aminophenylmercuric chloride in the amorphous state, while the 0-amino chloride separates in crystalline form. The mixture is sucked off, dried, and the 0- derivative extracted with not too much warm alcohol, separating as leaflets after the solution is chilled and allowed to stand The amorphous residue of p- chloride may be boiled with alcohol or benzene, and separates from the cold solution as leaflets melting at 1880, with decomposition. 

Synonyms Benzenemethanaminium, N-(3-aminopropyl)-N,N-dimethyl, N-babassu oil acyl derive., chlorides 1-Propanaminium, N,N-dimethyl-N-phenylmethyl-3-[(1-oxobabassu) amino]-, chloride... 

Uses Antistat, hair conditioner in cosmetics Cocamidopropyl PG-dimonium chloride Synonyms Cocamidopropyl dimethyl 2,3-dihydroxypropyl ammonium chloride 1-Propanaminium, N-(2,3-dihydroxypropyl)-N,N-dimethyl-3-[(1-oxococo-alkyl) amino]-, chloride Classification Quaternary ammonium salt Formula [RCO-... 

Synonyms Polydimethylaminopropyl methacrylamide methylchloride quaternium 1-Propanaminium, N,N,N-trimethyl-3-[(2-methyl-1-oxo-2-propenyl)amino]-, chloride, homopolymer... 

See Lauramidopropyl PG-dimonium chloride 1-Propanaminium, N-(2,3-dihydroxypropyl)-N,N-dimethyl-3-[(1 -oxoisooctadecyl) amino]-, chloride. See Isostearamidopropyl PG-dimonium chloride 1-Propanaminium, N,N-dimethyl-N-(aminocarbonylmethyl)-3-(1-oxococo alyl) amino-, chlorides. See,Quaternium-43 1-Propanaminium, N,N-dimethyl-N-carboxymethyl-3-amino-, N-mink oil acyl derivs., hydroxides, inner salts. See Minkamidopropyl betaine 1 -Propanaminium, N,N-dimethyl-N-(2,3-dihydroxypropyl)-3-[(1-oxodocosanyl) amino]-, chloride. See Behenamidopropyl PG-dimonium chloride... 

Propanaminium, 3-[(1-oxo-9-octadecenyl) amino]-N-ethyl-N,N-dimethyl-, ethyl sulfate (1 1) (salt). See Oleamidopropyl ethyidimonium ethosulfate 1 -Propanaminium, N-[(2-oxo-1 -pyrrolidinyl) methyl]-N,N-dimethyl-3-(1-oxooctadecyl) amino-, chloride. See Stearamidopropyl pyrrolidonylmethyl dimonium chloride 1-Propanaminium, N,N,N-trimethyl-2-hydroxy-3-(1-oxohexadecyloxy)-, chloride. SeePalmitoyl PG-trimonium chloride... 

Synonyms Cocamidopropyl dimethyl acetamido ammonium chloride 1-Propanaminium, N,N-dimethyl-N-(aminocarbonylmethyl)-3-(1-oxococo alyl) amino-, chlorides... 

Bartlett et aV showed that, in aqueous acetone solution, nitrogen mustard (1) dimerizes probably by the sequence of reactions shown in Scheme 1. The regeneration of the original amino chloride in the first reversible step no doubt contributed to the difficulties in obtaining reliable rate measurements. ... 

CA Index Name Xanthylium, 9-[2-[[4-[[(2,5-dioxo-l-pyrrolidinyl)oxy]carbonyl]-l-piperidinyl]sulfonyl]phe-nyl]-3,6-bis[methyl(4-sulfophenyl)amino]-, chloride (1 1)... 

Synonyms N-lsoslearamidopropyl-N,N-dlmelhyl-N-(dodecyl acetate) ammonium chloride 1-Propanaminium. N-carboxymethyl-N,N-dlmelhyl-3-[(1-oxolsooclade-cyl) amino]-, dodecyl ester, chloride 1-Propanamlnlum, N-[2-(dodecyloxy)-2-oxo-ethyl]-N,N-dlmethyl-3-[(1-oxoisooctadecyl) amino]-, chloride Classtficatton Quaternary amnnonlum salt Ionic Nature Cationic Empirical CjgHjjNjOs Cl Uses Antistat In cosmetics w/o and o/w emulsifier ManufAXstrib. Somerset Cosmetic Co. Variati... 

Propanaminium, N-(2,3-dihydroxypropyl)-N,N-dimethyl-3-[(1-oxococo-alkyl) amino]-, chloride. See Cocamidopropyl PG-dimonium chloride 1-Propanaminium, N-(2,3-dihydroxypropyl)-N,N-dimethyl-3-(1-oxododecy-lamino)-, chloride. See Lauramidopropyl PG-dimonium chloride 1-Propanaminium, N-(2,3-dihydroxypropyl)-N,N-dimethyl-3-[(1-oxoisooctadecyl) amino]-, chloride. See Isostearamidopropyl PG-dimonium chloride 1-Propanaminium, N,N-dimethyl-N-carboxymethyl-3-amino-, N-minkoil acyl derivs., hydroxides, inner salts. See Minkamidopropyl betaine 1-Propanaminium, N,N-dimethyl-N-(2,3-dihydroxypropyl)-3-[(1-oxodocosanyl) amino]-, chloride. See Behenamidopropyl PG-dimonium chloride 1-Propanaminium, N,N-dimethyl-N-ethyl-3-amino-, N-mink oil acyl derivs., ethyl sulfate (salts). See Minkamidopropyl ethyidimonium ethosulfate 1-Propanaminium, N,N-dimethyl-N-ethyl-3[(1-oxodocosanyl) amino]-, ethyl sulfate. See Behenamidopropyl ethyidimonium ethosulfate 1 -Propanaminium, N,N-dimethyl-N-phenylmethyl-3-[(1 -oxobabassu) amino]-, chloride. See Babassamidopropalkonium chloride 1-Propanaminium, N,N-dimethyl-3-sulfo-, N-coco acyl derivs., hydroxides, inner salts. See Coco-sultaine... 

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