1 -Amino-1 - -bromid

N,N-Bis(trifTuoromethyl)propadienylamine or l,3-his[N,N-bis(trifluoromethyl)]-aminopropadiene reacted with di(trifluoromethyl)amino bromide to give the center-attack products 264—266 [134],... 

Reaction of the salts 349 (Section III,D,4) with a number of primary amines and hydrazines gives the 11-amino bromides (350). Treatment of two of these salts [350 R = R = H, R = Me.NiCiU)., and NH CSNH] with base gives the free betaines [346 R = R2 = H, R = Me2N(CH2)3 and NH2CSNH] as stable solids. 

Tetrakis-[hydroxymethyl]- -chlorid E2, 53 Tetramethyl- -chlorid E2, 2 Tetraphenyl- E2, 114, 889 Tetraphenyl- -bromid E2, 113 Tetraphenyl- -jodid E2, 893 Trimethylsilylamino-triphenyl- E2 110 Triphenyl-(triphcnylphosphoranylidcn-amino)- -bromid E2. 111... 

Allyl-methyl-amino)-3-dimethyl-amino- -bromid E8d, 36 [5-NR2 - 3-( =NR) - 3H-1,2,4-dithiazol + Allyl-Br]... 

A stoichiometric, intramolecular variant of the Buchwald-Hartwig amination was reported by D, L. Boger and J, S. Panek as early as 1984 in the synthesis of lavendamycin.7 They showed that 1.2 equiv of Pd(PPh3)4 could effect the intramolecular cyclization of an amino bromide 1 to the desired heterocycle 2. The absence of an external base to sequester the generated HBr rendered this reaction super-stoichiometric in palladium. 

CftHiftBrNOS2, Bis(dimethylthionium)amino bromide monohydrate, 41B, 47 C5H9NOftS2f N-Methyl-2,2-dimethylsulphonylvinylideneamine, 18, 663 CgH,iNOftS2, N-Ethyl-2,2 -dimethylsulphonylvinylideneamine, 26, 604 C7H16CIO2N3S2, 1,3-Bis(thiocarbamoyl)-2-N,N-dimethylaminopropane hydrochloride, 46B, 63... 

First, the 2-azanorbomene precursor, 108, is obtained by the aqueous imino Diels-Alder reaction between cyclopentadiene and the iminium ion derived from formaldehyde and 2-bromoethylamine hydrobromide. Exposure of a solution of amino bromide 108 to silver triflate provides the spiroaziridinium salt, 109, in good overall yield. The ability of 109 to function as an alkylating agent has been demonstrated with a variety of enolates [37]. 

Place 425 ml. of concentrated ammonia solution (sp. gr. 0-88) in a 500 ml. round-bottomed flask and add slowly 75 g. of a-bromocaproic acid (Section 111,126). Stopper the flask tightly and allow it to stand in a warm place (50-55°) for 30 hours. Filter the amino acid at the pump and keep the filtrate A) separately. Wash the amino acid (ca. 26 g.) well with methyl alcohol to remove the ammonium bromide present. Evaporate the aqueous filtrate (A) almost to dryness on a steam bath. 

Carbonylation of halides in the presence of primary and secondary amines at I atm affords amides[351j. The intramolecular carbonylation of an aryl bromide which has amino group affords a lactam and has been used for the synthesis of the isoquinoline alkaloid 498(352], The naturally occurring seven-membered lactam 499 (tomaymycin, neothramycin) is prepared by this method(353]. The a-methylene-d-lactam 500 is formed by the intramolecular carbonylation of 2-bromo-3-alkylamino-l-propene(354]. 

Bis (meta or para haloacetyl) benzenes (C1CH2C0)2C6H4 condensed with thiourea yield the corresponding meta or para bis(4-thiazolyl-2-amino)phenylene (573, 574), analogous to 36 with R=NH2-By refluxing in alcohol solution m- or p-2-thiazolylphenacyl bromide (37) with thiourea, compound 111, in which R = H, Ph, P-CIC6H4, and p-OjNC H, was obtained (569). 

Polypeptide Synthesis and Analysis. Sihca or controUed-pore glass supports treated with (chloromethyl)phenylethyltrimethoxysilane [68128-25-6] or its derivatives are replacing chloromethylated styrene—divinylbenzene (Merrifield resin) as supports in polypeptide synthesis. The sdylated support reacts with the triethyl ammonium salt of a protected amino acid. Once the initial amino acid residue has been coupled to the support, a variety of peptide synthesis methods can be used (34). At the completion of synthesis, the anchored peptide is separated from the support with hydrogen bromide in acetic acid (see Protein engineering Proteins). 

Under certain circumstances bromine reacts with ammonia and amino compounds to form bromamide [14519-10-9] NH2Br, bromimide [14519-05-0], NHBr2, or nitrogen bromide [15162-90-0], NBr. These compounds can decompose explosively so great care should be exercised any time bromine and ammonia or amino compounds might come in contact with each other. 

There is also evidence for stable 3,4-adducts from the X-ray analysis of 2-amino-4-ethoxy-3,4-dihydropteridinium bromide, the nucleophilic addition product of 2-aminopteridine hydrobromide and ethanol (69JCS(B)489). The pH values obtained by potentiometric titration of (16) with acid and back-titration with alkali produces a hysteresis loop, indicating an equilibrium between various molecular species such as the anhydrous neutral form and the predominantly hydrated cation. Table 1 illustrates more aspects of this anomaly. 2-Aminop-teridine, paradoxically, is a stronger base than any of its methyl derivatives each dimethyl derivative is a weaker base than either of its parent monomethyl derivatives. Thus the base strengths decrease in the order in which they are expected to increase, with only the 2-amino-4,6,7-trimethylpteridine out of order, being more basic than the 4,7-dimethyl derivative. 

Amino-5-nitrosopyrimidines also condense with benzoylacetonitrile, phenacyl-pyridinium bromide and acetonylpyridinium chloride in the presence of sodium cyanide to produce. 7-amino-6-pteridinyl ketones (63JOC1197). Pteridine syntheses from pyridinium salts are not limited to the preparation of pteridyl ketones since pyridinium acetamide... 

Alkylation of 3-methyl-4-phenylisoxazolin-5-one with allyl bromide gave a mixture of N- and C(4)- alkylation in a 2 1 ratio. Heating the mixture changed the ratio to 1 99 and this conversion is believed to take place by an amino-Claisen rearrangement (Scheme 91) (69TL543). 

Benzo[a]quinoIizinium bromide, 7-methyl-electrochemical reductions, 2, 534 Benzo[c]quinolizinium bromide ring opening, 2, 533 Benzo[c]quinolizinium chloride hydrogenation, 2, 536 Benzo[c]quinoIizinium chloride, 6-amino-synthesis, 2, 554... 

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