2-Amino-2-methyl-1,3-dihydro- -bromid

Pteridinium bromide, 2-amino-4-ethoxy-3,4-dihydro-X-ray analysis, 3, 267 Pteridin-2-one, 4-amino-, 3, 273 hydrolysis, 3, 294 methylation, 3, 297 structure, 3, 273... 

Dimethoxy-3-methyl-l-(4-nitrophenyl)-iV-(5, 6 -dihydrothiazolo[3,2-b][l,2,4]triazol-2 -yl)isoquinolinmm bromide 45 is also prepared by reacting 4,5-dimethoxy-2-(4-nitrobenzoyl)phenylacetone 219 with 2-amino-5,6-dihydro-thiazolo[3,2- ][ 1,2,4]triazole 42 <2003JHC821, 2003JHC1041> (Equation 23). 

To obtain 2-amino-l,6-dihydro-8-azapurine, 96 (and its 2-methyl and 3-benzyl analogs) were refluxed with cyanogen bromide in methanol (4 h), giving 40-75% yields of the correspondingly alkylated products. 4-Amino-5-ethoxycarbonylaminomethyl-l,2,3-triazole (99) (from 96 and ethyl chloroformate), when refluxed in butanolic sodium butoxide (1 h), produced 7-methyl-l,6-dihydro-8-azapurin-2-one the 8-methyl and 9-ben-zyl analogs were made similarly (76-92% yield). ... 

Alkyl and arylmagnesium halides react with 2-methylquinoxaline by addition of one mole of reactant to the 3,4-bond. After hydrolysis the 2-alkyl- or 2-aryl-l,2-dihydro-3-methylquinoxalines (52) are obtained. When ethylmagnesium bromide is used a dimeric by-product (53) is also isolatedReaction of 2,3-dimethylquinoxaline with benzonitrile and lithium amide gives l-amino-l-phenyl-2-(3-methyl-2-quinoxalinyl)-ethylene (54). The mono- and dilithium salts of 2,3-dimethylquinoxaline have been generated from the quinoxaline by reaction with one or two equivalents of lithium diisopropylamide (LiNPr, respectively. These salts have been reacted with a variety of electrophilic reagents such as alkyl halides, aryl ketones, esters, and nitriles. " ... 

Ethyl (2E)-3-(dimethylamino)-2-(5-ethoxy-l-phenyl-lH-pyrazol-3-yl) propenoate (36) was prepared in two steps from ethyl (5-oxo-l-phenyl-4,5-dihydro-lH-pyrazol-3-yl)acetate (12) by treatment with ethyl bromide in ethanol under reflux to give ethyl (5-ethoxy-l-phenyl-lH-phenyl-3-yl) acetate (35), followed by treatment with DMFDM A in toluene under reflux. Compound 36 reacted with anilines, methyl glycinate hydrochloride, 3-amino-lf-f-indazole and 3-amino-5-methylisoxazol in ethanol in the... 

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