Amino acids permeases

Molecular cloning and nucleotide. sequencing of amino acid permease genes... 

Two additional permeases from Saccharomyces cerevisiae share lower homologies with this family of transporters. One of them is the UGA4 GABA-specific permease ([49], Fig. 2 and Andre, Hein, Grenson and Jauniaux, submitted) the second is the CTR choline transporter [50]. About 19% of the amino acid residues of these two proteins are identical. They show about 10% identity with each of the six amino acid permeases mentioned above. This identity does not include most of the amino acids which are highly conserved among the six permeases. 

Regulation of amino acid permease activity as a function of nitrogen availability... 

The APFl gene product, a common factor of unknown function which increases the activity of amino acid permeases... 

The regulation of NCR-sensitive amino acid transporters in Saccharomyces cerevisiae has many points in common with that of catabolic enzymes. Amino acid permeases, as well as some other transporters of nitrogenous nutrients, are integrated into the regulatory circuits, both general and specific, which control catabolic processes. 

General amino acid permease (Gapl) Springael and Andr6,1998... 

Regenberg, B., During-Olsen, L., Kielland-Brandt, M. C., Hohnberg, S. (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Current Genetics, 5(5,317-328. 

GAP1 General amino acid permease localization to the plasma membrane is regulated by nitrogen source... 

Curve D = acid phosphatase Curve E = cytidylyl transferase Curve F = amino acid permease... 

Akerman M, Shaked-Mishan P, Mazareb S et al. Novel motifs in amino acid permease genes fix>m Leishmania. Biochem Biophys Res Common 2004 325(l) 353-366. 

The basis for this orderly sequence of events appears to involve the nature and specificities of amino acid permeases. Thus, two general permeases may be involved, one showing specificity for group A and group C amino acids, since members of the former group compete with those of the latter [37], and one transporting group B amino acids. 

Berger, E. A. and Heppel, L. A. (1974) Different mechanisms of energy coupling for the shock-sensitive and shock-resistant amino acid permeases of Escherichia coli. J. Biol. Chem. 249, 7747-7755. 

---