Polyanhydrides amino acid-based

Amino acid based polyanhydrides Ricinoleic acid based polyanhydrides Polyanhydride with polyethylene glycol functionality... 

General methods for the synthesis of poly(amide-anhydrides) and poly(amide-esters) based on naturally occurring amino acids were described (Domb et at, 1990). The polymers were synthesized from dicarboxylic acids prepared by amidation of the amino group of an amino acid with a cyclic anhydride, or by the amide coupling of two amino acids with a diacid chloride. Low molecular weight polymers from methylene bis(p-carboxybenzamide) were symthesized by melt condensation (Hartmann et al, 1989). A series of amido containing polyanhydrides based on p-aminobenzoic acid were sy nthesized by melt condensation. The polymers melted at 58 to 177°C and had a molecular weight of 2500 to 12400. 

There are many polymers that are suitable for the production of nanoparticles employed for drug delivery, which can generally be divided into two groups natural polymers, e.g., polysaccharides (chitosan), proteins (albumin, gelatin), as well as synthetic polymers, e.g., polyesters (poly(lactic add), poly(glycolic add), poly(hydroxy butyrate), poly-e-caprolactone, poly-p-malic add, poly(dioxanones)) polyanhydrides (poly(adipic add)) polyamides (poly(amino acids)) phosphorous-based polymers (polyphosphate) poly(cyano acrylates) polyurethanes polyortho esters and polyacetals. Extreme attention has to be paid to the biodegradability and biocompatibility of the polymers. It is essential that polymers used for medical applications are not detrimental for the tissue or cells and that they can be easily decomposed into simple harmless molecules and eliminated by the human body [ 18-22]. 

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