Amines, organometallic compounds with imines

The corresponding aryl and alkyl silylimines undergo reaction in the same way but much fastCT requiring only one equivalent of the organometallic compound (Table S). With silylimines, the reaction is complete in less that one hour at -78 C. The yields of amines are somewhat Iowa- than those obtained with aluminum imines. In fact the trimethylsilylimines behave in part as silylating reagents toward organometallic compounds. 

Through the ester enolate-imine route, we have been able to prepare with high diastereo-and enantio-selectivity carbapenems such as PS-5 and PS-6 as well as ip-methyl carbapenems and monobactams. A promising application is represented by the stereospecific synthesis of chiral aziridines, potential starting materials for the preparation of a- and P-amino acids. Metallo imines also undergo reaction with a number of organometallic compounds to give primary amines and chiral 1,2-aminols. 

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