Amides, degradation

HOFMANN Amide Degradation Degradation o( amides to amines by means of hypohaiides... 

Thus, it may be assumed that, in analogy with the Hofmann acid amide degradation, the —CONH2 group of the carbamoyl complex is oxidized to NCO". 

Understandably, these compounds having cis CO groups do not undergo a Hofmann acid amide degradation to give the respective hydrido complexes. The stability of these Group VIIIB carbamoyl complexes increases in the order Fe, Ru, Os. 

HOFMANN Amide degradation 173 HOFMANN IsonitrHe synthesis 173 HOFMANN Elimination 174 HOFMANN LOEFFLER - FREYTaG Pyrrolidine synthesis 175... 

Amide degradation. In a liquid triphasic system made up of NaOCl, NaBr, a phase-tranfer agent, Na3P04, benzene, and water, primary amides are degraded to nitriles of one fewer carbon atom. After Hofmann rearrangement the amine products undergo bromination and eventually elimination. 

Urethans from carboxylic acid amides Degradation with loss of 1 -atom... 

Ochrobactrum anthropi SV3 was isolated as a D-valine amide degrader after a 4-month acclimation of bacterial culture. The strain produced an enzyme that was characterized as o-amino acid amidase (DaaA) [5], Furthermore, Bacillus cereus DF4-B excreted alkaline o-peptidase (ADP), which acted on the synthehc oligopeptide D-phenylalanine tetramer (o-Phe). The enzyme was characterized as the first endopeptidase acting on D-amino acid-containing peptides by recognizing the second amino acid from its N-terminus under alkaline conditions [6]. 

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