Alzheimer s amyloid-/? peptide

Wood SJ, Maleeff B, Hart T, Wetzel R (1996) Physical, morphological and functional differences between pH 5.8 and 7.4 aggregates of the Alzheimer s amyloid peptide A. J Mol Biol 256(5) 870-877... 

The two partners are the membrane and the infectious protein (e.g., Alzheimer s -amyloid peptide Ap, Parkinson s associated a-synuclein, and HIV-1 gpl20) (Fig. 14.1A-C). Each of these proteins faces a complex membrane formed by a collection of lipids with wide biochemical diversity. Hopefully, among the myriad of brain membrane lipids, the protein generally selects a preferred target, most often located in a lipid raft microdomain. For instance, Ap peptides interact preferentially with ganglioside GMl, and a-synuclein with GM3. ... 

---