Altitude hemoglobin adaptations

Weber, R. (1995). Hemoglobin adaptations to hypoxia and altitude—the phylogenetic perspective. In Hypoxia and the Brain, pp. 31-44, ed. 

Immediate treatment of altitude sickness includes hydration, rest, and if necessary, descending to a lower altitude. The adaptation to lowered oxygen levels requires about 10 days. During this time the bone marrow increases red blood cell production, providing more red blood cells and more hemoglobin. A person living at a high altitude can have 50% more red blood cells than someone at sea level. This... 

BPG levels are elevated In the RBCs of persons who have adapted to high altitude conditions, enhancing dissociation of02 In tissues to compensate for reduced O2 saturation of hemoglobin. 

Godovac-Zimmetmann,Kosters,)., Braunitzer, G. Goltenboth, R. (1988). Structural adaptation of bird hemoglobins to high-altitude respiration and the primary sequences of black-headed gull (Lams ridibundus, Charadriiformes) err-... 

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