Alteration of Liver P450 Expression by Hormonal Perturbation

Alteration of Liver P450 Expression by Hormonal Perturbation 

The anticancer drugs cisplatin cyclophosphamide - and ifosfamide alter the profile of P450 enzyme expression in liver and perhaps other tissues, at least in part due to the hormonal perturbations that these cytotoxic agents induce. Treatment of adult male rats with a single dose of cisplatin depletes serum androgen, and this effect persists for up to 28 days after drug administration . Serum androgen depletion by cisplatin is associated with a feminization of hepatic liver enzyme expression. Thus, cisplatin-treated male rats have elevated levels of the female-predominant 

Other drugs that suppress hepatic CYP2C11 and CYP3A2 levels include chloramphenicol and cyclosporine . The effects of chloramphenicol are strain-specific, occurring in Sprague-Dawley rats but not in Fischer 344 rats. Moreover, this suppression is accompanied by a modest reduction in plasma levels of th5U oxine but not testosterone. GH does not appear to play a 

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