Alpha spectrin

Buevich, A. V., Lundberg, S., Sethson, I., Edlund, U., and Backman, L. (2004). NMR studies of calcium-binding to mutant alpha-spectrin EF-hands. Cell Mol. Biol. Lett. 9, 167-186. 

Dubreuil, R. R., Byers, T. J., Sillman, A. L., Bar-Zvi, D., Goldstein, L. S., and Branton, D. (1989). The complete sequence of Drosophila alpha-spectrin Conservation of structural domains between alpha-spectrins and alpha-actinin. J. Cell Biol. 109, 2197-2205. 

Lundberg, S., Bjork, J., Lofvenberg, L., and Backman, L. (1995). Cloning, expression and characterization of two putative calcium-binding sites in human non-erythroid alpha-spectrin. Eur. J. Biochem. 230, 658-665. 

Moon, R. T., and Lazarides, E. (1983). Beta-spectrin limits alpha-spectrin assembly on membranes following synthesis in a chicken erythroid cell lysate. Nature 305, 62-65. 

B. G. (1990). The complete cDNA and polypeptide sequences of human erythroid alpha-spectrin. / Biol. Chem. 265, 4434-4443. 

Wessel, G. M., and Chen, S. W. (1993). Transient, localized accumulation of alpha-spectrin during sea urchin morphogenesis. Dev. Biol. 155, 161-171. 

Alpha spectrin (a-spectrin) A cytosolic protein that maintains cellular structural integrity and is susceptible to calpain and caspase cleavage. 

Sadqi, M., Casares, S., Ahril, M. A., Lopez-Mayorga, O., Conejero-Lara, F., and Freire, E. (1999). The native state conformational ensemble of the SH3 domain from alpha-spectrin. Biochemistry 38, 8899-8906. 

Pauli J, van Rossum B, Forster H et al (2000) Sample optimization and identification of signal patterns of amino acid side chains in 2D RFDR spectra of the alpha-spectrin SH3 domain. J Magn Reson 143 411 16... 

Morel B, Casares S, Coneja-o-Lara F (2006) A single mutation induces amyloid aggregation in the alpha-spectrin SH3 domain analysis of the early stages of fibril formation. J Mol Biol 356 453-468... 

Pike BR, Zhao X, Newcomb JK, Posmantur RM, Wang KK, Hayes RL (1998) Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury. Nemoreport 9 2437-2442... 

Davison, M. D., and Critchley, D. R. (1988). Alpha-actinins and the DMD protein contain spectrin-like repeats. Cell 52, 159-160. 

Viel, A. (1999). Alpha-actinin and spectrin structures An unfolding family story. FEBS Lett. 460, 391-394. 

Woods, C. M., and Lazarides, E. (1985). Degradation of unassembled alpha- and beta-spectrin by distinct intracellular pathways Regulation of spectrin topogenesis by beta-spectrin degradation. Cell 40, 959-969. 

Ylanne, J., Scheffzek, K., Young, P., and Saraste, M. (2001b). Crystal structure of the alpha-actinin rod Four spectrin repeats forming a tight dimer. Cell Mol. Biol. Lett. 6, 234. 

Proteomic studies have revealed additional FRAPs that are not PDZ proteins (17,24,29). Examples of these FRAPs include components of the actin-spectrin cytoskeleton (e.g., beta-actin, spectrin alpha II chain) and the intracellular signaling apparatus (e.g., calmodulin, and protein kinase C [PKC]0-interacting protein). 

Alpha fodrin Spectrin alpha chain Alpha-II spectrin, fodrin alpha chain... 

Alam MR, Johnson RC, Darlington DN, Hand TA, Mains RE, Eipper BA (1997) Kalirin, a cytosolic protein with spectrin-like and GDP/ GTP exchange factor-like domains that interacts with peptidylgly-cine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme. J Biol Chem 272 12667-12675. 

Alpha-Actinin is a rod-like (3-4 nmx 30-40 nm) cytoskeletal protein belonging to the same family as spectrin, dystrophin and utrophin. a-Actinin is a homodimer with a subunit molecular weight of 94-103 kDa in which the subunits are antiparallel in orientation. The molecule can be devised into three domains, an N-terminal actin binding domain (approximately residues 1-245), four internal 120 residue repeats, and a C-terminal region containing two EF-hand Ca -binding motifs (Baron et al. 1987, Blanchard et al. 1989). Apart from actin, a-actinin has been reported to bind to the cytoskel-... 

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