Alpha-crystallinity

Figure 19.3 Crosshatched microstructure of alpha crystalline isotactrc polypropylene...

Seidler, N. W., Yeargans, G. S., and Morgan, T. G. (2004). Carnosine disaggregates glycated alpha-crystallin An in vitro study. Arch. Biochem. Biophys. 427,110-115. 

Schey, K.L., Patat, S., Chignell, C.E, Datillo, M., Wang, R.H., and Roberts, J.E. (2000) Photooxidation of lens alpha-crystallin by hypericin (active ingredient in St. John s wort). Photochem Pho-tohiol 72 200-2003. 

Nicholl, I. D., and Quinlan, R. A. (1994). Chaperone activity of alpha-crystallins modulates intermediate filament assembly. EMBO J. 13, 945-953. 

Ferro, D. R., Bruckner, S., Meille, S. V. and Ragazzi, M. (1992). Energy calculations for isotactic polypropylene—a comparison between models of the alpha-crystalline and gamma-crystalline structures. Macromolecules, 25, 5231-5. [182]... 

The above definition of molecular chaperone is entirely fnnctional and contains no constraints on the mechanisms by which different chaperones may act. The term noncovalent is nsed to exclude those proteins that carry out posttranslational covalent modifications. Protein disulfide isomerise may seem to be an exception, bnt it is both a covalent modification enzyme and a molecular chaperone. It is helpful to think of a molecnlar chaperone as a fnnction rather than as a molecnle. Thns, no reason exists why a chaperone function shonld not be a property of the same molecnle that has other fnnctions. Other examples include peptidyl-prolyl isomerase, which possesses both enzymatic and chaperone activities in different regions of the molecnle, and the alpha-crystallins, which combine two essential fnnctions in the same molecnle in the lens of the eye-contribnting to the transparency and the refractive index reqnired for vision as well... 

Crabbe, M.J., Cataract as a conformational disease - the Maillard reaction, alpha-crystallin and chemotherapy. Cell Mol Biol 44 (1998) 1047-1050. 

Poly(ethylene 2,6-naphthalate) (PEN) film containing alpha, beta and amorphous phases were prepared, and the amorphous contribution digitally subtracted to yield the characteristic spectra of the amorphous, alpha, and beta phases. In other words, the amorphous spectrum is determined by melting the polymer, so after subtraction, one knows the spectrum of all of them. The alpha crystal form adopts an all-rran conformation, while the beta crystal form adopts a conformation with appreciable gauche character. Conformational changes in PEN occur due to the rotation of the naphthalene ring as well as rotation of the ethylene glycol units. The normalised absorbances of the bands at 824 and 814 cm were correlated to polymer density, and can be used to represent the amorphous and alpha crystalline phases, respectively (56). 

Figure 19.2 Molecular helix of alpha crystalline form ofisotactic polypropylene.

Alpha-crystalline PA66 (Planar H-bonded sheet structure)... 

Han, J. Schey, K. L. MALDI tissue imaging of ocular lens alpha -crystallin. Invest. Ophthalmol Vis. Sci. 2006, 47, 2990-2996. 

Uses 0/w emulsifier alpha-ending emulsifier alpha-crystalline stabilizer for sponge cake foaming gel... 

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