Allosteric binding site

However, the testing of a wide range of concentrations of an allosteric antagonist would show the saturation of the allosteric binding site as revealed by an approach to a maximal value for the antagonism. The Schild equation for an allosteric antagonist is given by (see Section 7.8.3)... 

Jakubic, J., Bacakova, L., Lisd, V., El-Fakahany, E. E., and Tucek, S. (1996). Activation of muscarinic acetylcholine receptors via their allosteric binding sites. Proc. Natl. Acad. Sci. USA 93 8705-8709. 

Recently, many NNl of HCV NS5B RNA polymerase have been discovered and these were recently reviewed (Condon et al. 2005). One allosteric binding site has... 

Ellis J. Allosteric binding sites on muscarinic receptors. Drug Dev Res 1997 40 193-204. 

Figure 2. Stereoview of the allosteric binding site of fructose 1,6-bisphosphatase and the binding geometry of AMP (yellow).

Malherbe, P. N. K., Knoflach, F Zenner, M. T et al. (2003) Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, non-competitive antagonist of the metabotropic glutamate 1 receptor. J. Biol. Chem. 278,8340-8347. 

Reviewed in Christopoulos, A. Allosteric binding sites on cell-surface receptors novel targets for drug discovery. Nat. Rev. Drug Discov. 2002, 1, 198-210. 

The regulation of ribonucleotide reductase is complex. The substrate-specificity and activity of the enzyme are controlled by two allosteric binding sites (a and b) in the R1 subunits. ATP and dATP increase or reduce the activity of the reductase by binding at site a. Other nucleotides interact with site b, and thereby alter the enzyme s specificity. 

J. (2002) Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat Struct Biol 9, 268-272. 

Fig. 9 The putative allosteric binding site where laulimahde and peloruside could bind the moving aB9-B10 loop is represented in red , the tubulin subunits are represented in gold (a) and silver (P)...

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