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Toxic epidermal necrolysis allopurinol

Stevens-Johnson syndrome and toxic epidermal necrolysis e.g. anticonvulsants, sulphonamides, aminopenicillins, oxicam NSAIDs, allopurinol, chlormezanone, corticosteroids. [Pg.308]

Two of nine patients with drug-induced toxic epidermal necrolysis were taking hydrochlorothiazide, one with triamterene and allopurinol, the other with reserpine and hydralazine both died (28). [Pg.3377]

Adverse reactions to allopurinol, particularly toxic epidermal necrolysis and a hypersensitivity syndrome, are reputed to be more common in patients taking thiazides, but evidence to support this is hard to find (SEDA-11, 198) (SEDA-13,188). [Pg.3378]

Jarzobski J, Ferry J,Womboldt D, Fitch DM, Egan JD Vasculitis with allopurinol therapy. Am Heart J 1970 79 116-121. KantorGC.Toxic epidermal necrolysis, azotemia, and death afterallopurinol therapy. JAMA 1970 212 478-479. [Pg.478]

The cutaneous reaction caused by allopurinol is predominantly a pruritic, erythematous, or maculopapular eruption, but occasionally the lesion is urticarial or purpuric. Rarely, toxic epidermal necrolysis or Stevens-Johnson syndrome occurs, which can be fatal. The risk for Stevens-Johnson syndrome is limited primarily to the first 2 months of treatment. Because the rash may precede severe hypersensitivity reactions, patients who develop a rash should discontinue allopurinol. If indicated, desensitization to allopurinol can be carried out starting at 10—25 fjbg/day, with the drug diluted in oral suspension and doubled every 3—14 days until the desired dose is reached. This is successjul in approjdmately half of patients. Oxypurinol is available for compassionate use in the U.S. for patients intolerant of allopurinol. The safety of oxypurinol in patients with severe allopurinol hypersensitivity is unknown it is not recommended in this setting. [Pg.460]

Kaniwa N, Saito Y, Aihara M, Matsunaga K, Tohkin M, Kurose K, Sawada J, Finuya H, Takahashi Y, Muramatsu M, Kinoshita S, Abe M, Ikeda H, Kashiwagi M, Song Y, Ueta M, Sotozono C, Ikezawa Z, Hasegawa R (2008) HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis. Pharmacogenomics 9 1617-1622... [Pg.489]

Skin Allopurinol has commonly been implicated in Stevens—Johnson syndrome and toxic epidermal necrolysis [85 ]. This association has been confirmed by an analysis from Singapore. Of 85 cases of Stevens-Johnson syndrome and toxic epidermal necrolysis managed in Singapore from 2003 to 2007, allopurinol was implicated in 13 cases [86 ]. The HLA-B 5801 allele is associated with severe cutaneous adverse reactions caused by allopurinol in the Han Chinese population [87 ]. The association between allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis and HLA-B 5801 has also been confirmed in Thai and Japanese patients [88 89. ... [Pg.250]

Fagot JP, Bouwes Bavinck JN, Sidoroff A, Naldi L, Dunant A, Viboud C, Roujeau JC. EuroSCAR Study Group. Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel. J Am Acad Dermatol 2008 58(1) 25-32. [Pg.256]

Skin reactions may occur in up to 10% of patients given allopurinol and are more likely in patients with renal impairment. Severe reactions such as toxic epidermal necrolysis (Lyell s syndrome) have been reported (191 —193 ). It is, however, only reasonable to stress that these patients have sometimes been receiving other drugs as well, including phenylbutazone, which is known to cause Lyell s syndrome, and diuretics (192 ). [Pg.94]

Sisca, T. S. (1975) Toxic epidermal necrolysis secondary to allopurinol therapy. J. din. Pharmacol, 15, 566. [Pg.102]


See other pages where Toxic epidermal necrolysis allopurinol is mentioned: [Pg.192]    [Pg.189]    [Pg.428]    [Pg.256]   
See also in sourсe #XX -- [ Pg.250 ]




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