Tolbutamide Allopurinol

Other drugs Acetazolamide, acetosulfone, acetylcysteine, acitretin, allopurinol, aminoglutehimide, benzaflbrate, brompheniramine, calcium dobe-silate, chloropheniramine, chlorpropamide, colchicine, deferiprone, dapsone, flutamide, glibenclamide, hydroxychloroquine, mebhydro-lin, meprobamate, metapyrilene, methazolamide, metochlopramide, prednisone, promethazine, retinoic acid, riluzole, ritodrine, tolbutamide, yohimbine... 

Allopurinol, chloramphenicol, isoniazid Antipyrine, dicumarol, probenecid, tolbutamide... 

Toxic (especially sclerosing) cholangitis (5,8,17-19,24,38, 39, 44-46) has been attributed to the effects of aromatic amines. Likewise, this condition can be caused by lithocholic acid. It may also be triggered by various medicaments acting as facultative toxins, e. g. allopurinol, antibiotics, carbamazepine, phenylbutazone, tolbutamide, (s. tab. 29.6) Such a type sometimes occurs after intra-arterial administration of cytostatics (18, 19, 24, 38) and as a result of burn injuries. (44) (s. p. 651) (s. tab. 32.4)... 

The following drugs have been most often associated with erythema multiforme and Stevens-Johnson syndrome allopurinol, lamotrigine phenytoin, barbiturates, carbamazepine, estrogens/progestins, gold, NSAIDs, penicillamine, sulfonamides, tetracycline, and tolbutamide. 

Noninterfering acetaminophen, acyclovir, allopurinol, amoxicillin, amphotericin B, am-picillin, aspirin, azlocillin, bendrofluazide, bumetanide, buprenorphine, carbenidllin, cefazolin, cefotaxime, cefoxitin, ceftazidime, cefuroxime, cephalexin, chlorambucil, chloramphenicol, chlordiazepoxide, chlorpheniramine, chlorpropamide, cyclophosphamide, cyclosporin, C5d arabine, daunorubicin, dextropropoxyphene, dihydrocodeine, domperidone, flucytosine, furosemide, gentamicin, griseofulvin, melphalan, methotrexate, metochlo-pramide, metronidazole, miconazole, nabilone, netilmicin, nicotinamide, nitrazepam, penicillin G, piperacillin, prednisolone, procarbeizine, prochlorperazine, riboflavin, rifampin, sulfamethoxazole, thioguanine, tobramycin, tolbutamide, trimethoprim... 

Other Allopurinol, chlopropamide, gold salts, penicillamine, tolbutamide... 

Allopurinol 2.5 mg/kg twice daily for 15 days reduced the half-life of intravenous tolbutamide in 10 healthy subjects by 25%, from 360 to 267 minutes. ... 

Information is very limited. Only gliclazide has been implicated in severe hypoglycaemia with allopurinol and there seem to be no reports of either grossly enhanced hypoglycaemia with chlorpropamide and allopurinol, or a reduced effect with tolbutamide and allopurinol. More study is needed to find out whether any of these interactions has general clinical importance, but it seems unlikely. 

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