Allergy inhibitors

Constit. of latex of Dyera lowii and in the leaves of Anodendron affine. Also from Nerium oleander, Trachelospermum jasminoides and other plants. Latex used for manuf of chewing gum. Allergy inhibitor. Cryst. (EtOH) with sweet taste. Mp 210°. Exhibits polymorphism. Opt. inactive (meso-). 

USE Intermediate for the preparation of allergy inhibitor [7825]. l-(5,6,7,8-Tetrahydro-2-hydroxy-3-propyl-l-naphthalenyl)-l-propanone... 

BIOLOGICAL ACTIVITY Antibiotic [8086] antibiotic-resistant bacteria [8062] for biliary and urinary tract disorder treatment [8087] antagonist against both thromboxane A and leukotriene [8088] antimicrobial for staphylococcus aureus [6891] as allergy inhibitor [8089] vesicular stomatitis virus inhibition [8059],... 

Its chief use is as a component in photographic developers. Because the free compound is unstable in air and light, it is usually marketed as the sulfate salt [55-55-0] Metol, mp 260°C (dec.). It also finds appHcation as an intermediate for fur and hair dyes and, under certain circumstances, as a corrosion inhibitor for steel. Prolonged exposure to 4-(/V-methy1amino)pheno1 has been associated with the development of dermatitis and allergies. 

Malbran A, Hammer C, Frank M. Fries L Acquired angioedema observations on the mechanism of action of autoanfibodies directed against C1 esterase inhibitor. J Allergy Clin Immunol 1988 81 1199-1204. 

Zuraw B, Sugimoto S, Curd J The value of rocket Immunoelectrophoresis for C4 activation in the evaluation of patients with angioedema or Cl-inhibitor deficiency. J Allergy Clin Immunol 1986 78 1115-1120. 

Schneider L. Lumry W Vegh A, Wilhams A, Sch-malbach T Critical role of kallikrein in hereditary angioedema pathogenesis a chnical trial of ecallan-tide, a novel kaUikrein inhibitor. J Allergy Clin Immunol 2007 120 416-422. 

Martin L, Raison-Peyron N. Nothen M. Cichon S. Drouet C Hereditary angioedema with normal Cl inhibitor gene in a family with affected women and men is associated with the p.Thr328Lys mutation in theP12gene.J Allergy Chn Immunol 2007 120 975-977. 

McAlexander L, Sinha T, et al Dipeptidyl peptidase IV deficiency increases susceptibifity to angiotensinconverting enzyme inhibitor-induced peritracheal edema. J Allergy Chn Immunol 2007 120 403-408. 

COX-2 in asthma pathogenesis and its significance in the use of selective inhibitors. Clin Exp Allergy 2002 32 339-342. 

History. This includes the severity grading of the clinical reaction, the time of administration and onset of symptoms, the concomitant use of other drugs, foods or compounds (latex), previous history of drug allergy, atopy in the personal or family history, other underlying conditions such as mastocytosis or Cl esterase inhibitor deficiency. The actual preparation in its galenic identity should be stored or at least listed. 

Stumpf JL. Shehab N. Patel AC Safety of angiotensin-converting enzyme inhibitors in patients with insect venom allergies. Ann Pharmacother 2006 40 699-703. 

Holgate ST, Bradding P, Sampson AP. Leukotriene antagonists and synthesis inhibitors new directions in asthma therapy. J Allergy Clin Immunol 1996 98 1-13. 

Some medicines, such as non-steroid anti-inflammatory drugs, convertase inhibitors, and (3-blockers, may intensify food allergy symptoms (Brooks et ah, 1989 Meune et ah, 2000 Tenenbaum et ah, 2000). 

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