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Allergic reactions modification

Observable toxic responses in the skin (irritation, allergic reaction) can be directly caused by the presence of surfactant molecules in the dermis, by inflammatory mediators (cytokines) liberated by keratinocytes, or by other substances penetrating the epidermis after the skin barrier function has been impaired by surfactants. The damage of hair fibers is closely related to the impairment of the cuticle layer, which can cause modifications in the mechanical and optical properties of the hair. Substantial differences exist between the mechanisms of skin damage and hair damage, but for the purposes of our discussion, only the common initial event of surfactant-keratin interaction will be considered. [Pg.456]

Although the antibacterial spectmm is similar for many of the sulfas, chemical modifications of the parent molecule have produced compounds with a variety of absorption, metaboHsm, tissue distribution, and excretion characteristics. Administration is typically oral or by injection. When absorbed, they tend to distribute widely in the body, be metabolized by the Hver, and excreted in the urine. Toxic reactions or untoward side effects have been characterized as blood dyscrasias crystal deposition in the kidneys, especially with insufficient urinary output and allergic sensitization. Selection of organisms resistant to the sulfonamides has been observed, but has not been correlated with cross-resistance to other antibiotic families (see Antibacterial AGENTS, synthetic-sulfonamides). [Pg.403]


See other pages where Allergic reactions modification is mentioned: [Pg.710]    [Pg.363]    [Pg.27]    [Pg.344]    [Pg.415]    [Pg.142]    [Pg.1418]    [Pg.340]    [Pg.299]    [Pg.153]    [Pg.252]    [Pg.231]    [Pg.232]    [Pg.214]    [Pg.657]    [Pg.80]    [Pg.796]    [Pg.878]    [Pg.18]    [Pg.13]    [Pg.258]    [Pg.272]    [Pg.328]    [Pg.438]    [Pg.161]    [Pg.167]    [Pg.499]    [Pg.348]    [Pg.568]    [Pg.120]    [Pg.74]    [Pg.393]    [Pg.31]    [Pg.155]   
See also in sourсe #XX -- [ Pg.499 ]




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Modification reaction

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