Allergens and Noncellular Respiratory Components

In addition to interacting with cells in the respiratory system, it is also possible that allergens interact with a variety of acellular components within the respiratory tract owing to electrostatic properties, enzymatic activity, or carbohydrate content. For example, basic proteins bind to the sialic acid-rich mucins present in high concentration in respiratory secretions owing to electrostatic interactions 

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Epithelial permeability owing to Mast cell degranulation Tight junction degradation Kinin generation 

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