Alkylation and Allylation Adjacent to a Carbonyl Group

1 The RiiH2(CO)(PPh3)3-CATALYSED ALKYLATION, ALKENYLATTON AND ARYLATION OL AROMATIC KETONES VIA CARBON-HYDROGEN BOND CLEAVAGE 

Fumitoshi Kakiuchi, Satoshi Ueno and Naoto Chatani. 14 

2 Catalytic, asymmetric synthesis of ihoi-disubstituted amino acids using a chiral 

COPPER-SALEN COMPLEX AS A PHASE TRANSFER CATALYST 

3 Alkylation of alanine methyl ester Schiff base by chiral salen-metal catalysts, 

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Sosnicki and Struk were also able to apply their allyl/alkyl lithium magnesiate base in a one-step symmetrical double alkylation of lactams at the challenging carbon site adjacent to the carbonyl group [78]. The dual alkylation was assigned to the reactivity of Bu2Mg which was believed to be extruded after the first alkylation but is basic enough to execute a second magnesiation (Fig. 26b). 

Thus, this Volume is divided into 12 Chapters encompassing different types of carbon-carbon bond forming reactions. The first two experimental Chapters cover alkylation reactions adjacent to carbonyl functionality (Chapter 2) and the asymmetric displacement of acetate groups situated in an allylic position with the resultant formation of optically active product possessing a new carbon-carbon bond (Chapter 3). 

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