Alkylamines oxidase

Norinder, U., Florvall, L. and Ross, S.B. (1994). A PLS Quantitative Structure-Activity Relationship Study of Some Monoamine Oxidase Inhibitors of the Phenyl Alkylamine Type. Ear. J.Med.Chem.,29,191-195. 

Hasegawa, K, Kimura, T, Miyashita, Y. and Funatsu, K. (1996) Nonlinear partial least squares modeling of phenyl alkylamines with the monoamine oxidase inhibitory activities./. Chem. Inf. Comput. Sci., 36, 1025-1029. 

B. Mechanism-Based Inhibition of Monoamine Oxidase Unsaturated Alkylamines. .. 340... 

Irreversible Inhibitors of Monoamine Oxidase Unsaturated AlkylAmines... 

D-Giucose oxidase co-immobilized with catalase by glutaraldehyde-mediated reaction with alkylamine glass has been used in an enzyme thermistor for continuous measurement of D-glucose in the effluent from a column reactor. The two enzymes have also been co-immobilized by adsorption onto a mixture of glutaraldehyde and diaminobenzene copolymerized in the presence of pumice and titanium oxide carrier particles. The enzymatic oxidation of D-glucose was then studied in a differential-bed loop reactor. Deactivation of D-glucose oxidase was found to remain small in the presence of excess immobilized catalase. A mathematical model was developed to describe the experimental results. 

Marques, I. D. H. C., E. T. A. Marques, A. C. Silva, W. M. Ledingham, E. H. M. Melo, V. L. da Silva, and J. L. Lima Filho. 1994. Ascorbic acid determination in biological fluids using ascorbate oxidase immobilized on alkylamine glass beads in a flow injection potentiometric system. Appl. Biochem. Biotechnol. 44 81-89. 

N,N-Dimethylttyptamine (DMT) is a representative of the tryptamin i.e. indole-3-alkylamine, family. Note the stmc-tural similarity to serotonin which is 5-hydroxyttyptamine (Fig. 18.33). DMT is parenterally, but not orally, active at around 60-100 mg of the free base since rapid deamination by monoamine oxidase oteurs following oral administration. Pharmacological effects are therefore induced by inhalation of the free base vapour or by injection of a water-soluble salt. The fumarate salt has been used in a number of human dinical studies and it was reported that the psychoactive effects are relativdy short-lived, with durations less than 1 horn. Smoking of the free base leads to very intense but short-lived effects for around 5-15 minutes. A number of N-mono and dimethylated tryptamines are also present in several human tissues. Thdr exact function has been debated for several decades but so far no definite condusion has been reached. 

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