Alkyl aryl ethers information

RATE INFORMATION FROM CONSTANT INTENSITY IRRADIATION OF ALKYL ARYL ETHERS... 

More detailed kinetic information about the motions and reactions of the alkyl/aryloxy radical pairs can be obtained if the alkyl carbon atom making an ether bond is chiral and the alkyl aryl ether is optically active. Because the radical centers of the alkyl fragments derived from irradiation of such ethers are either planar or invert very rapidly, they exist initially with their aryloxy partners as prochiral pairs. Their ability to retain the memory of the chirality of their parent ethers and impart it to the rearrangement products depends on the ratio between the in-cage rates of radical tumbling and radical pair combination. 

The mechanism of the final step of C-0 bond formation by a formal reductive elimination was included as part of Chapter 11. In particular, two model systems have provided information on the mechanism of this reaction. First, the reaction orders, solvent effects, and electronic effects on the reductive elimination of methyl acetate and methyl aryl ethers from methylplatinum(lV) acetate and phenoxide complexes (Equation 18.16 and Scheme 18.4) indicated that these reductive eliminations occur by backside attack on a platinum methyl. Second, a study of the stereochemistry of the attack of water on a Pt(lV) alkyl showed that the formation of alcohol occurred with the inversion of configuration that reflects a backside attack. ... 

A9.6.4.7 The Nordic Council of Ministers issued a report (Pederson et al, 1995) entitled Environmental Hazard Classification, that includes information on data collection and interpretation, as well as a section (5.2.8) entitled QSAR estimates of water solubility and acute aquatic toxicity . This section also discusses the estimation of physicochemical properties, including log Kow For the sake of classification purposes, estimation methods are recommended for prediction of minimum acute aquatic toxicity, for ...neutral, organic, non-reactive and non-ionizable compounds such as alcohols, ketones, ethers, alkyl, and aryl halides, and can also be used for aromatic hydrocarbons, halogenated aromatic and aliphatic hydrocarbons as well as sulphides and disulphides, as cited in an earlier OECD Guidance Document (OECD, 1995). The Nordic document also includes diskettes for a computerized application of some of these methods. 

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