Alkaloid corynanthe alkaloids

L-tyrosine Tyrosine-derived alkaloids Indole alkaloids Quinoline alkaloids /3-carboline alkaloids Pyrroloindole alkaloids Ergot alkaloids Iboga alkaloids Corynanthe alkaloids Aspidosperma alkaloids Protoalkaloids Terpenoid indole alkaloids True alkaloids... 

B. CORYNANTHE ALKALOIDS 1. Antirhine and Antirhine jVb-Metho Salts... 

Dihydrocorynantheol (21), first isolated from Aspidosperma marcgravianum (147), is the simplest corynanthe alkaloid. The members of this type of alkaloid have three stereo centers in the D ring of the indolo[2,3-a]quinolizine skeleton. This substitution pattern allows four possible relative arrangements for the C-3, C-15, and C-20 stereo centers, the names of which are normal, pseudo, alio, and epiallo, respectively. 

From lactams 266 and 267 the 18,19-didehydro alkaloid corynantheal (258) and its stereosiomers with pseudo and epiallo configurations have also been prepared in racemic form (154). 

An interesting transformation was discovered by Sakai and Shinma (181) during the chemical investigation of corynanthe alkaloid (V-oxides. Polonovski reaction and sodium cyanoborohydride reduction of hirsuteine A-oxide (331) gave corynantheine (52) and 3-isocorynantheidine (65), the latter likely formed by reduction of the conjugated iminium intermediate 334. 

Aspidosperma alkaloids These alkaloids have an aspidosperma-type nucleus. The a and are the same as in corynanthe type. Catharantine is the P4 from cathenamine (Figure 68). 

Alkaloids like preakuammicine (Figure 6.79) and akuammicine (Figure 6.75) contain the C10 and C9 Corynanthe type terpenoid units respectively. They are, however, representatives of a subgroup of Corynanthe alkaloids termed the Strychnos type because of their structural similarity to many of the alkaloids found in Strychnos... 

Terpenoid Indole Alkaloids.—Crude preparations from Catharanthus roseus seedlings and from tissue cultures have been shown to be capable of synthesizing in good yield from tryptamine (110) and secologanin (111) with added co-factors, geisso-schizine (112) and ajmalicine (113), representatives of the first major class of terpenoid indole alkaloids (Corynanthe). Geissoschizine was metabolized to ajmalicine and several other unidentified alkaloids (for reviews of biosynthesis in intact plants see ref. 106). The catabolic turnover of vindoline and catharanthine in C. roseus has been studied. ... 

The analogous photocyclisation of enamides is well known and is of particular value in synthesis. Photocyclisation of the enamides (29) to the furopyridones (30), for example, has been used in the preparation of key intermediates for alkaloid synthesis. Similar approaches have been employed in the synthesis of corynanthe alkaloids ° and in the preparation of trans-hexahydro-indolo[43-ab]phenanthridines as selective dopamine agonists. The benzoylmethylenebenzothiazepines (31) can be converted in the same way into the B-homo-5-thiaprotoberberines (32). Enamide photocyclisation has also been employed in the syntheses of halo-benzofuro[2,3-c]quinolines,benzo[h][l]- and benzo[/j[1]-benzo-... 

Averaged values from three different Corynanthe alkaloids. 

Sakai and Shinma were interested in the chemical correlation of the Corynanthe alkaloids with those of the C-mavacurine type and have carried out a number of successful transformations in this area (189,190). 

However, very recently in a series of biomimetic experiments it has been established that under virtually physiological conditions vincoside is transformed into akuammigine (140b) and strictosidine into tetrahydroalstonine (139b) and ajmalicine i.e. the precursor for the 3a Corynanthe alkaloids was the 3a glycoalkaloid and hence no inversion at C-3 was required (73). Concurrent biosynthetic work on V. rosea it was found that strictosidine was... 

Quite recently Zenk and co-workers have shown that strictosidine is also a biological precursor for terpenoid indole alkaloids of 3fl configuration. The biosynthetic conversion proceeds with loss of hydrogen at C-3, while it is retained in the formation of 3 a, Corynanthe alkaloids (107). 

Table II tabulates the plant species which contain the complex indole alkaloids. The letters in this table correspond to the various structural types as coded in Figs. 2 and 3. Types I, II, and III are the major variations of the Cfl-Ci 0 unit which, in combination with tryptamine, formally elaborate the three significantly different groups of complex indole alkaloids Corynanthe, Iboga, and Aspidosperma. Such initial classification follows the outline set by Battersby [3, 3a) and others (2, 4, 5). The...

Pawelka and Stockigt (5S5) identified eight different indole alkaloids from cell suspension cultures of O. elliptica. The pattern of the alkaloids found was quite different from the above-mentioned results reported by Kuoadio and co-workers (779). The alkaloids identified were tetrahydroal-stonine, cathenamine, pleiocarpamine and two other methoxy-substituted heteroyohimbine alkaloids Corynanthe/heteroyohimbine type), norfluo-rocurarine Strychnos type), and apparicine and epchrosine Aspi-dosperma type). The last mentioned alkaloid was a new compound (729) not known from intact plants. 

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