Ergot alkaloids, synthesis

Thus, our tungstate method is proved to be applicable even to ergot alkaloids. Synthesis of 316 and various 1-hydroxy derivatives of ergot alkaloids could be carried out in the near future. 

In ergot alkaloid synthesis does not become appreciable until the sphacelial stage gives rise to sclerotia. Unpublished experiments in the author s laboratory (Groger) indicate that there is no change in the ratio of the alkaloids as the ergot matures. 

Keywords. Ergot, Alkaloid synthesis, Claviceps, Directed biosynthesis. Bioreactors... 

Kalinin, A.V., Chauder, B.A., Rakhit, S. and Snieckus, V. (2003) seco-C/D ring analogues of ergot alkaloids. Synthesis via intramolecular Heck and ring-closing metathesis reactions. Org. Lett., 5, 3519-21. 

Naidoo, B., Cassady, J.M., Blair, G.E. and Floss, H.G. (1970) Biosynthesis of ergot alkaloids. Synthesis of chanoclavine-I-aldehyde and its incorporation into elymoclavine by Claviceps. J. Chem. Soc. Chem. Comm., 471—472. 

Kfen, V., Olsovsky, P., Havlicek V., Sedmera, P., Witvrouw, M. and De Clercq, M. (1997h) N-Deoxyrihosides of ergot alkaloids Synthesis and biological activity. Tetrahedron, 53,4503 510. 

Rao, K.K., Gupta, A.R. and Singh, V.K. (1977) Effect of phosphate on ergot alkaloid synthesis in Aspergillus fumigatus. Folia Microbiol., 22,415—416. 

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