Alkalizing agents sodium bicarbonate

Lactic acidosis, which typically accompanies hypovolemic shock as a consequence of tissue hypoxia, is best treated by reversal of the underlying cause. Administration of alkalizing agents such as sodium bicarbonate has not been demonstrated to have any... 

Sodium bicarbonate Alkalizing agent Corrects lactic acidosis... 

Several alkalization agents have been developed as possible alternatives to sodium bicarbonate. These include carbicarb (a mixture of sodium carbonate and sodium bicarbonate) and tris-hydroxymethylaminomethane (also called THAM or tromethamine). These agents theoretically produce a lesser increase in plasma carbon dioxide tension and, therefore, less CSF and intracellular acidosis. However, this does not appear to be the case for tromethamine, which resulted in a decrease in CSF pH similar to sodium bicarbonate in healthy horses (Pedrick et al 1998). 

TRIS is one of the most common buffers used in the biology/biochemistry labs. It is used as alternative to sodium bicarbonate in the treatment of metabolic acidosis. It is also an emulsifying agent and absorbent for acidic gases, alkalizer and osmotic diuretic. 

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