Aliphatic halogen compounds carbon tetrachloride

For one-carbon halogenated aliphatics, HOMO decreases as the number of chlorines increases. HOMO is a measure of the ability of a compound to donate electrons (i.e., to act as a nucleophile or undergo oxidation) therefore, an increase in chlorine numbers increases the reactivity of the molecule. The dataset is chloromethane, dichloromethane, chloroform, and carbon tetrachloride. HOMO represents 99.90% of the variance in the linear regression equation. The probability of getting a correlation of -0.9995 for a sample size of four is less than 2%. 

In the reactions with aliphatic hydrogen-containing compounds such as hexane, and halogen compounds such as carbon tetrachloride, hydrogen and halogen respectively are abstracted from these compounds these are reactions characteristic of active free radicals. 

Organic solvents, which induce CYP2E1, are comprised of a few broad chemical classes, including hydrocarbons such as benzene and toluene, halogenated aliphatic compounds such as carbon tetrachloride and dichloroethane, aliphatic alcohols such as ethanol, and hydroxyethers such as 2-methoxyethanol. Industrial solvents are frequently mixtures of several compounds. The most frequent solvent-associated toxicity occurs from occupational exposure. A number of organic solvents have been examined for their effects on the immune system, and the requirement for their bioactivation to produce immunotoxicity has been well established. 

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