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Aldosterone receptor blockade

Anavekar NS, Solomon SD. Angiotensin II receptor blockade and ventricular remodelling. J Renin Angiotensin Aldosterone Syst. 2005 6 43-48. [Pg.344]

Wehling M. Effects of aldosterone and mineralocorti-coid receptor blockade on intracellular electrolytes. Heart Fail Rev. 2 005 10 39-46. [Pg.413]

Another example of a GeMM transgenic model displaying clinical like conditions including cardiac hypertrophy, fibrosis, and heart failure is the a-myosin heavy chain promoter 11 p-hydroxysteroid dehydrogenase type 2 transgenic mouse (18). Eplerenone (INSPRA , Pfizer Inc.), a selective aldosterone blocker, was tested in this model and proved to ameliorate the phenotype. This model revealed the deleterious consequences of inappropriate mineralocorticoid receptor activation in the heart and supported the notion that aldosterone blockade may provide additional therapeutic benefit in the treatment of heart failure. [Pg.40]

Combination studies Dual blockade of the renin-angiotensin-aldosterone system by combined use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists may provide more renal protection than monotherapy in chronic kidney disease. In 45 patients with chronic kidney disease who took either enalapril 20 mg/day or candesartan 16 mg/ day for 16 weeks followed by treatment, with incremental dosing of enalapril (target... [Pg.321]

See other pages where Aldosterone receptor blockade is mentioned: [Pg.32]    [Pg.26]    [Pg.32]    [Pg.26]    [Pg.336]    [Pg.226]    [Pg.104]    [Pg.417]    [Pg.28]    [Pg.33]    [Pg.214]    [Pg.143]    [Pg.160]    [Pg.1025]    [Pg.467]    [Pg.620]    [Pg.247]    [Pg.238]    [Pg.406]    [Pg.417]    [Pg.754]    [Pg.416]    [Pg.293]    [Pg.51]   


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