Albumin genetic variants

DEAE 25W were operated in tandem to map the peptides generated on tryptic hydrolysis of very large proteins, such as albumin genetic variants.197 A useful review that covers many aspects of peptide analysis is available.198... 

Amino Acid Substitutions and Codon Changes for Albumin Genetic Variant ... 

Takahashi, N., Takahashi, Y., Ishioka, N., Blumberg, B., and Putnam, F. W., Application of an automated tandem high-performance liquid chromatographic system to peptide mapping of genetic variants of human serum albumin, J. Chromatogr., 359, 181, 1986. 

Kragh-Hansen U, Brennan SO, Galliano M, Sugita O. Binding of warfarin, salicylate, and diazepam to genetic variants of human semm albumin with known mutations. Mol Pharmacol 1990 37[2] 238—242. 

The proteins of milk fall into several classes of polypeptide chains. These have been delineated most completely in bovine milk, and a system of nonmenclature has been developed for them (Chapter 3 Eigel et al. 1984). One group, called caseins, consists of four kinds of polypeptides asr, as2-. and 3-, and k- with some genetic variants, post translational modifications, and products of proteolysis. Almost all of the caseins are associated with calcium and phosphate in micelles 20-300 fim in diameter (see Chapter 9). The other milk proteins, called whey proteins, are a diverse group including /3-lactoglobulin, a-lactalbumin, blood serum albumin, and immunoglobulins (Chapter 3). Almost all... 

AAG (orosomucoid) is synthesized and metabolized by the liver with a half-life of approximately 5.5 days and is an a 1-globulin protein that is smaller (MW 40,000) than albumin. It is an acute phase reactant, and concentrations increase in stress situations including diseases. At least four polymorphic patterns and four genetic variants in human plasma have been reported. ... 

Adverse reactions to human serum albumin are uncommon and usually mild, such as itching and urticaria. Serious reactions are rare. A patient who has reacted violently to albumin on one occasion may tolerate it well on another after being given an antihistamine such as diphenhydramine (1). Aggregates present in protein preparations may be the cause of some reactions. Another postulated cause may be the presence of antibodies against genetic variants of human albumin (2). Hypotensive reactions due to the presence of a prekallikrein activator in some batches of formulations can occur. 

Naylor DH, Anhorn CA, Laschinger C, Males F, Chodirker WB. Antigenic differences between normal human albumin and a genetic variant. Transfusion 1982 22(2) 128-33. 

Weitkamp LR, Salzano FM, Neel JV, Porta F, Geerdinf RA, Tarnoky AL (1973) Human serum albumin twenty-three genetic variants and population distribution. Ann Hum Genet 36 381-392... 

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