Alb-VP-hPXR transgenic mice

Alb-VP-hPXR Transgenic Mice Expressing the Activated hPXR... 

FIGURE 7.4 Creation of VP-PXR transgenic mice. Schematic representation of the Alb-VP-hPXR transgene construct, and transgene expression in the liver of transgenic mice. 

The FABP-VP-hPXR mice were subsequently used to confirm that, like their Alb-VP-hPXR counterparts, activation of hPXR in this transgenic line also resulted in the disruption of adrenal steroid homeostasis [40] and promotion of hepatic steatosis [31]. 

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