Protein oxidation aging

Carney, J.M., Starke-Reed, P.E., Oliver, C.N., Landrum, R.W., Cheng, M.S. and Wu, J.F. (1991). Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-cr-phenylnitrone. Proc. Natl Acad. Sci. USA 88, 3633-3636. 

PRION PLAQUE EORMATION PROTEIN OXIDATION (In Aging Disease) PROTEIN PRENYLTRANSFERASES... 

Bulteau, A. L., Szweda, L. I., and Friguet, B. (2006). Mitochondrial protein oxidation and degradation in response to oxidative stress and aging. Exp. Gerontol. 41, 653-657. 

Small JG, Klapper MH, Milstein V, et al Garbamazepine compared with lithium in the treatment of mania. Arch Gen Psychiatry 48 915-921, 1991 Smeyne RJ, Klein R, Schnapp A, et al Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368 246-249, 1994 Smith GD, Garney JM, Starke-Reed PE Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer s disease. Proc Natl Acad Sci USA 85 10540-10543, 1991... 

Methylation,125 hydroxylation, and other irreversible modifications often affect specific residues in a protein, Oxidative alterations occur during aging of proteins (Chapter 18).126 A few proteins even undergo "splicing" that alters the amino acid sequence (Box 29-E).127 All of these reactions not only affect the properties of the proteins but also participate in driving the turnover of these macromolecules. 

Berlett BS, Stadtman ER. 1997. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272 20313-20316. 

Poon HF, Calabrese V, Calvani M, Butterfield DA. 2006. Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by 1-acetylcamitine Insights into the mechanisms of action of this proposed therapeutic... 

Beal, M. F. (2004). Therapeutic effects of coenzyme Q10 in diseases. Methods Eneymol. 382, 473-487. Beal, M. F., and Matthews, R. T. (1997). Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment ofneurodegenerative diseases. Mol. Aspects Med. 18(Suppl.), 169-179. Berlett, B. S., and Stadtman, E. R. (1997). Protein oxidation in aging, disease, and oxidative stress. 

Increased levels of ROS due to oxidative stress have been consistently found in cardiovascular diseases as atherosclerosis or hypertension [18]. There is certain evidence that the free radicals involved in Parkinson s disease are mainly due to the production of increased levels of free radicals during oxidative metabolism of dopamine [19]. Oxidative stress, manifested by protein oxidation and lipid peroxidation (LP), among other alterations, is a characteristic of Alzheimer s disease [20] and in the pathogenesis of diabetes related complications. Treatment with antioxidants seemed to be a promising therapeutic option for these diseases [21], The inflammatory nature of rheumatoid arthritis implies that a state of oxidative stress may also exist in this disease [22,23]. Also, free radicals have a certain role in Huntington s disease [24,25], age related degeneration [26], and some autoimmune disorders [27],... 

Sohal, R. Role of oxidative stress and protein oxidation in the aging process. Free Radi. Biol. Med. 33(1), 37—44, 2002. 

Not all data confirm accumulation of protein oxidation products with age. For example, comparison of 9-month-old and 24-month-old female Long-Evans/Wistar hybrid rats did not demonstrate any age-related increase of o-tyrosine and 3-nitrotyrosine in the heart, skeletal muscle, and liver. These observations were interpreted as indications suggesting that proteins damaged by the hydroxyl radical and reactive nitrogen species did not accumulate in these tissues with advancing age (L7). Dityrosine could not be detected in human plasma proteins or haemoglobin (with the detection limit of 1 pmol/mg protein) (D3), but may accumulate in... 

At. Agarwal, S., and Sohal, R. S., Relationship between susceptibility to protein oxidation, aging, and maximum life span potential of different species. Exp. Gerontol. 31, 365—372 (1996). 

C2. Cao, G., and Cutler, R. G., Protein oxidation and aging. I. Difficulties in measuring reactive protein carbonyls in tissues using 2,4-dinitrophenylhydrazine. Arch. Biochem. Biophys. 320, 106-114 (1995). 

D21. Dubey, A., Forster, M. J., Lai, H., and Sohal, R. S., Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch. Biochem. Biophys. 333, 189-197 (1996). 

F19. Fu, S., Fu, M. X., Baynes, J. W., Thorpe, S. R., and Dean, R. T., Presence of dopa and amino acid hydroperoxides in proteins modified with advanced glycation end products (AGEs) Amino acid oxidation products as a possible source of oxidative stress induced by AGE proteins. Biochem. J. 330, 233-239 (1998). 

L7. Leeuwenburgh, C., Hansen, P., Shaish, A., Holloszy, J. O., and Heinecke, J. W., Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats. Am, J. Physiol. 274, R453-R461 (1998). 

Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., etal., Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc. Natl. Acad. Set USA 88, 10540-10543 (1991). 

Stadtman, E.R., and Berlett, B. S., Reactive oxygen-mediated protein oxidation in aging and disease. Chem. Res. Toxicol. 10, 485-494 (1997)... 

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