Agelasine

A saponin-like substance, agelasine, was isolated from Agelas dispar (10). Suber-itine from Suberites domcunculus was originally isolated by Richet (32) and was shown to be heat labile and have a MW of 28,000 by Cariello et al. (33). A cyclic peptide, dolastin, was isolated from Dolabella awicularia (34). 

Agelasine, 320 Aiptasia pallida, 304,310 Aiptasia species, toxic protein, 321 Aiptasiolysin, 304,310 Alexandrium dinoflagellates clones, 36,38-3 saxitoxin source, 21 toxicity, 36... 

Table 2 New purine derivatives from marine sponges agelasines A-F and ageline B.

Latonduines A (137) and B (138), have been isolated from the Indonesian sponge Stylissa carteri [163]. Their skeleton caimot be derived from the C Ns building block of the oroidins it has been proposed that ornithine is the biogenetic precursor to the aminopyrimidine fragment of the latonduines. Agelasine G (139), a new... 

The natural product (-P)-agelasine D 73 has been synthesized for the first time from adenine derivative 71. The terpenoid moiety was readily available from the diterpene alcohol (-i-)-manool 69<04TL4233>. 

Ca2+ channels are inhibited by several bis-isoquinoline alkaloids (e.g., berbamine, hernandezine, liensinine, monterine, tetrandine), aporphines (e.g., glaucine, norushinsunine), complex indole alkaloids (bis-nortoxiferine, hirsutine, mitragynine, paspaline, paspalitrem, paxilline, penitrem), or other bulky alkaloids (agelasine, contotoxins, crambescidin, ryanodine). Many channel blocker occur in animal venoms it has been estimated that 10% of marine natural products have these properties [65]. 

Aral M, Yamamo Y, SetiawanA,KobayashiM. Identification of the target protein of agelasine D, a marine sponge diterpene alkaloid, as an anti-dortmant mycobacterial substance. Chembiochem 2014 15(l) 117-23. 

Agelasines J, K, and L from a Solomon Islands Marine Sponge... 

Debitus and coworkers [90] isolated and characterized three new diterpene alkaloids, agelasines J—K from extracts of the marine sponge Agelas cf... 

Table 15 chemical shift assignments for agelasine J (100) and agelasine L (101) Position Agelasine J (100) Agelasine L (101)... 

Nakamura, H., H. Wu, Y. Ohizumi, and Y. Hirata Agelasine-A, -B, -C, and -D, Novel Bicyclic Diterpenoids with a 9-Methyladeninium Unit Possessing Inhibitory Effects on Na,K-ATPase from the Okinawan Sea Sponge Agelas sp. Tetrahedron Lett. 25, 2989 (1984). 

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