Agelas agelasins from

A saponin-like substance, agelasine, was isolated from Agelas dispar (10). Suber-itine from Suberites domcunculus was originally isolated by Richet (32) and was shown to be heat labile and have a MW of 28,000 by Cariello et al. (33). A cyclic peptide, dolastin, was isolated from Dolabella awicularia (34). 

Debitus and coworkers [90] isolated and characterized three new diterpene alkaloids, agelasines J—K from extracts of the marine sponge Agelas cf... 

Nakamura, H., H. Wu, Y. Ohizumi, and Y. Hirata Agelasine-A, -B, -C, and -D, Novel Bicyclic Diterpenoids with a 9-Methyladeninium Unit Possessing Inhibitory Effects on Na,K-ATPase from the Okinawan Sea Sponge Agelas sp. Tetrahedron Lett. 25, 2989 (1984). 

Fu, X Schmitz, F.J., Tanner, R.S., and Kelly-Borges, M, (1998c) Agelasines H and 1, 9-methyladenine-containing diterpenoids from an Agelas sponge. J. Nat. Prod., 61, 548-550. 

Wu, H., Nakamura, H., Kobayashi, J., Ohizumi, Y, and Hirata, Y. (1986) Structures of agelasines, diterpenes having a 9-methyiadeninium chromophore isolated from the Okinawan marine sponge Agelas nakamurai Hoshino. Bull. Chem. Soc.Jpn., 59,2495-2504. 

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