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AGE-RAGE interactions

Also, interaction of AGEs with their receptors is thought to generate oxidative stress. Cellular interactions of AGEs are mediated by specific cellular binding proteins, receptors for AGE (RAGE). AGE-albumin or AGEs isolated from plasma of... [Pg.206]

In summary, our data clearly indicate that particularly CML, but also casein-bound CML, can activate the SOD as one of the major antioxidant enzymes via interaction with RAGE. Increased SOD activity may (1) counteract the formation of superoxide radical anions in response to RAGE-mediated NADPH-oxidase activity and may also (2) reduce the amount of AGEs that is formed from oxidative pathways. Therefore, interaction of an AGE such as CML with RAGE may activate cellular defense mechanisms against ROS. Rising levels of AGEs may, therefore, be based on a combination of the dietary intake, in vivo formation and cellular defense mechanisms. [Pg.19]

See other pages where AGE-RAGE interactions is mentioned: [Pg.220]    [Pg.222]    [Pg.13]    [Pg.180]    [Pg.181]    [Pg.220]    [Pg.222]    [Pg.13]    [Pg.180]    [Pg.181]    [Pg.197]    [Pg.194]    [Pg.1]    [Pg.1]    [Pg.3]    [Pg.12]    [Pg.135]    [Pg.1105]    [Pg.119]    [Pg.122]    [Pg.207]    [Pg.1105]    [Pg.158]    [Pg.176]    [Pg.155]    [Pg.172]    [Pg.202]    [Pg.2]    [Pg.12]    [Pg.70]    [Pg.71]    [Pg.247]   
See also in sourсe #XX -- [ Pg.220 ]



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