Aetiocholanolone fever

Fever Fever often occurs for the most part, it remains at 38 °C, but septic temperatures are possible. In some cases, this may well be a question of aetiocholanolone fever, whereby aetiocholanolone can also be quantified in the serum. Bacterial infections are likewise a cause of fever and require appropriate treatment. Toxins may also be responsible for the febrile condition (tissue toxins, endotoxins), (s. p. 738)... 

The degradation products of androgenous steroids are a further suspected cause of such febrile episodes, since severe fever could be induced by i.m. injection of aetiocholanolone (3a-hydroxy-5p-H-androstane-17-on) (A. Kappas et af, 1957). In 1958 P. K. Bondy et al. for the first time detected an increase in aetiocholanolone in the plasma of patients with unexplained fever episodes, and thus they coined the term aetiocholanolone fever. Other steroids of the 5p-H configuration also revealed this pyrogenic feature. Aetiocholanolone may be the product of disturbed hepatocellular metabolism. Further observations and examinations have meanwhile been reported. (51, 136)... 

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