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Adverse, drug reactions delivery system

The nitrates are available in various forms (eg, sublingual, transmucosal, translingual spray, and inhalation). Some adverse reactions are a result of the metiiod of administration. For example, sublingual nitroglycerin may cause a local burning or tingling in the oral cavity. However, die patient must be aware that an absence of this effect does not indicate a decrease in the drug s potency. Contact dermatitis may occur from use of die transdermal delivery system. [Pg.381]

Hogan, D.J. Maibach, H.I. Adverse dermatologic reactions to transdermal drug delivery systems. J. Am. Acad. Dermatol. 1990, 22 (5 Pt 1), 811-814. [Pg.2710]

In pharmaceutical preparations, soybean oil emulsions are primarily used as a fat source in total parenteral nutrition (TPN) regimens. Although other oils, such as peanut oil, have been used for this purpose, soybean oil is now preferred because it is associated with fewer adverse reactions. Emulsions containing soybean oil have also been used as vehicles for the oral and intravenous administration of drugs drug substances that have been incorporated into such emulsions include amphotericin, " diazepam, retinoids, vitamins, poorly water-soluble steroids, fluorocarbons, and insulin. In addition, soybean oil has been used in the formulation of many drug delivery systems such as liposomes, microspheres, dry emulsions, self-emulsifying systems, and nanoemulsions and nanocapsules. ... [Pg.722]

Since the human respiratory tract is anatomically and physiologically a very heterogeneous system, the rate and extent of absorption of macromolecules as well as their potential adverse reactions depend on the regional doses. The most convenient method to deliver drugs to the respiratory tract is by inhalation. Other methods of delivery such as intratracheal instillation are used in experimental settings but are generally unsuitable for real-life therapeutic products. This section... [Pg.2734]


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