Adult Neural Stem Cells and Cellular Therapy

Adult Neural Stem Cells and Cellular Therapy [Pg.19]

Neurogenesis may also occur, albeit at lower levels, in other areas of the brain, such as the Ammon s horn CA1, neocortex and substantia nigra (SN) in certain species [8-10]. However, some of these reports have been contradicted by other studies, and need to be further investigated [11-14]. In the adult spinal cord, recent studies have confirmed that gliogenesis, but not neurogenesis, occurs throughout the cord [15, 16]. [Pg.20]

The origin and identity of NSCs remain source of debate and controversy [1]. Though recent reports further support an astroglial origin for newly-generated neuronal cells [25-29], NSCs are yet to be unequivocally identified in the adult brain. There are currently no specific markers of adult NSCs. The intermediate neurofilament nestin, the transcription factors sox-2, oct-3/4, and the RNA binding protein Musashi 1 are markers for neural progenitor and stem [Pg.21]

With the confirmation that neurogenesis occurs in the adult brain, and the recent isolation and characterization in vitro of neural progenitor and stem cells from the adult CNS, new avenues for the treatment of neurological diseases and injuries are being considered. Cell therapeutic interventions may involve both in vivo stimulation and transplantation of neural progenitor and stem cells. [Pg.22]

Reprinted from Taupin P. Adult neural stem cells and cellular therapy. Journal of Stem Cells (2006) 1(1) 47-55, with permission from Nova Science Publishers, Inc. [Pg.26]

Adult Neural Stem Cells A Model of Choice for Cellular Therapy for CNS Diseases and Injuries... [Pg.25]

Taupin, P. (2006). Adult neural stem cells, neurogenic niches and cellular therapy. Stem Cell Reviews, 2, 213-9. [Pg.39]

The isolation and characterization of neural progenitor and stem cells from the adult brain has tremendous potential for developmental biology and cellular therapy. Because neural progenitor and stem cells can be differentiated into the three major cell types of the nervous system, they provide a model to study the development and function of the adult mammalian... [Pg.94]

The confirmation that neurogenesis occurs in the adult brain and that NSCs reside in the adult CNS opens new opportunities for cellular therapy. Cell therapy would involve the stimulation of endogenous neural progenitor or stem cells, or the transplantation of adult-derived neural progenitor and stem cells to repair the degenerated pathways. [Pg.96]

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