Adsorbents aluminum hydroxide adjuvant

Wittayanukulluk, A. et al.. Effect of microenvuonment pH of aluminum hydroxide adjuvant on the chemical stability of adsorbed antigen, Vaccine. 22, 1172, 2004. 

The aluminum hydroxide gel referred to in the USP 28 is used in cosmetics as an emollient, filler, humectant, a mild astringent, and viscosity controlling agent. In pharmaceutical preparations it is used as an adsorbent, and as a protein binder. It is also used therapeutically as an antacid, and as an abrasive in dentrifrices. It is not, however, used as a vaccine adjuvant. 

There also is a marketed Lyme disease vaccine containing recombinant OspA (31,115,116). The vaccine is a sterile suspension of a noninfectious recombinant vaccine containing an immunodominant outer surface protein of Borrelia burgdorferi known as lipoprotein OspA. The antigen is adsorbed onto aluminum hydroxide as an adjuvant. Vaccine efficacy against definite Lyme disease is 78% after three doses. 

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