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Adriamycin binding properties

The DNA-binding properties of anthraquinones have been studied intensively over the past 25 years because of their clinical potential as anticancer drugs. The anthraquinone system is often found in anti-tumor drugs such as anthracyclines, mitoxantrone (11a), ametantrone (11b) and derivatives thereof [217-220]. Mitoxantrone (11a) and ametantrone (11b) have attracted much interest because of their lower risks of cardiotoxic effects compared with the naturally occurring anthracyclines doxorubicine (adriamycin) (4b) and daunorubicin [221]. [Pg.179]

The DNA forms stable complexes with doxorubicin (Adriamycin, ADR) and daunorubicin (DNR). Doxorubicin and DNR, although structurally similar, show distinctly different properties ADR is more toxic and active than DNR in the treatment of various human solid tumors the apparent binding affinity of ADR to DNA is about 1.8 times higher than that of DNR to DNA. Trouet et al. [229] found the ADR-DNA complex to be more active than ADR, DNR, or DNR-DNA in subcutaneously inoculated leukemic mice, whereas the DNR-DNA complex showed the highest... [Pg.570]

This anticancer drug causes the scission of single-strand DNA amongst its various biological properties. Here, too, the reaction involves binding of Fe11 by adriamycin and the reduction of... [Pg.729]

See other pages where Adriamycin binding properties is mentioned: [Pg.591]    [Pg.277]    [Pg.42]    [Pg.43]    [Pg.73]    [Pg.277]    [Pg.76]    [Pg.124]    [Pg.459]    [Pg.140]    [Pg.143]    [Pg.146]    [Pg.147]    [Pg.150]    [Pg.156]    [Pg.140]    [Pg.143]    [Pg.146]    [Pg.147]    [Pg.150]    [Pg.156]    [Pg.1106]   
See also in sourсe #XX -- [ Pg.140 , Pg.149 ]

See also in sourсe #XX -- [ Pg.140 , Pg.149 ]



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