Administration, animal health drugs

Food and Drug Administration, in Microbiological Significance of Drug Residues in Foods, Symp., June 8, Food and Drug Administration, Animal Health Institute and Center for Veterinary Medicine, Rockville, MD (1992). 

Most of the data regarding inhalation exposure to chloroform in humans were obtained from clinical reports describing health effects in patients under anesthesia. In some instances, the results may have been confounded by the concurrent administration of other drugs with chloroform or by artificial respiration of patients under chloroform anesthesia. Furthermore, most of the studies did not provide any information regarding actual exposure levels for observed effects. Nonetheless, chloroform-induced effects in humans are supported by those observed in animals under experimental conditions. The human studies cited in the profile provide qualitative information on chloroform toxicity in humans. 

Edds, G.T. (1979). Aflatoxin, In Conference on Mycotoxins in Animals Feeds and Grains Related to Animal Health, pp. 80-85. Bureau of Veterinary Medicine, Food and Drug Administration, Rockville, Maryla ... 

Food and Drug Administration, Animal Dmgs, Feeds, and Related Products Enro-floxacin for Poultry Withdrawal of Approval of a New Animal Dmg Application, 90 Fed. Reg. 44,048 (2005) Nestle, Safe Food, 46 World Health Organization, Overcoming Antimicrobial Resistance (2000) (mounting evidence) Alicia Mundy Jared Favole, FDA Calls Off Ban on Animal Antibiotics, WSJ, December ro, 2008, at B3 Marian Burros, F.D.A. Proposal on Meat Safety Draws Criticism, NYT, June 8, 1983, at Cl. 

When it approved the New Animal Drug AppHcation (NADA) of formalin, FDA ruled that use of formalin for fisheries was safe for humans and the environment. They ruled that effluents from fish treatments at 250 mg/L should be diluted 10 times and from egg treatments 75 times if 1,000 —2,000 mg/L were used (10,11). Before registering the compound, FDA also addressed carcinogenicity by stating it was not concerned about human exposure from either water or fish treated with formalin. The U.S. Fish and Wildlife Service (USFWS) has procedural guidelines that should protect workers from harm fill levels of formalin. Calculations based on treatment levels demonstrated that a fishery worker is exposed to not more than 0.117 mg/L formalin in the air, well below the levels estabUshed by the U.S. Occupational Safety and Health Administration to protect workers. 

Guideline for Approval No. 3 General Principles for Evaluating the Safety of Compounds Used in Food-producing Animals. Revised July 1994. US Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Veterinary Medicine, RockvUle, MD(1994). 

Past chlordane use, coupled with atmospheric transport as the major route of dissemination, produced global contamination of fish and wildlife resources and human populations. The chemical and its metabolites were frequently detected in all species examined, but usually at low concentrations. Residues in fish muscle sometimes exceeded the U.S. Food and Drug Administration action level of 0.3 mg/kg fresh weight recommended for human health protection. In general, chlordane in animals is highest near areas where the chemical has been applied to control termites concentrations are highest in fat and liver, especially in predatory species. 

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