Adenosine antiarrhythmic effects

The effects of adenosine are potentiated in patients receiving dipyridamole, an adenosine-uptake inhibitor, and in patients with cardiac transplants owing to denervation hypersensitivity. Methylxanthines, such as theophylline and caffeine, block adenosine receptors therefore, larger than usual doses are required to produce an antiarrhythmic effect in patients who have consumed these agents in beverages or as therapy. 

DIPYRIDAMOLE ANTIARRHYTHMICS t effect of adenosine 1 doses needed to terminate supraventricular tachycardias case report of profound bradycardia when adenosine infusion was given for myocardial stress testing Dipyridamole inhibits adenosine uptake into cells l bolus doses of adenosine by up to fourfold when administering it to treat supraventricular tachycardias. Some recommend avoiding adenosine for patients taking dipyridamole. Advise patients to stop dipyridamole for 24 hours before using adenosine infusions... 

Diprosone betamethasone. diprOtin A is a tripeptide that is an ENZYME INHIBITOR with selectivity as an aminopeptidase inhibitor active against dipeptidylpeptidase IV (EC 3.4.11). It can be used as a pharmacological tool in experimental analytical studies, dipyridamole [ban, inn, usan] (Persantin ) is a pyrimidine derivative, a coronary VASODILATOR, a (class la) ANTIARRHYTHMIC, an adenosine UPTAKE INHIBITOR causing indirect adenosine receptor activation, and enhances effects of anticoagulants and is a platelet AGGREGATION INHIBITOR. 

The hypotensive effects of adenosine receptor agonists probably are of limited (commercial) use, in view of the overwhelming number of therapeutic strategies already in clinical practice. On the contrary, the potentially beneficial metabolic, antiarrhythmic and CNS effects also elicited by these compounds are confounded by the cardiovascular actions. Thus, the clinical development of an adenosine receptor agonist as a novel antipsychotic was discontinued due to its cardiovascular toxicity [6]. 

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