Adenine compounds

Drury, A. N. Szent-Gyorgyi, A. (1929). The physiological activity of adenine compounds with special reference to their action upon mammalian heart. 

Drury AN, Szent-Gyorgyi A (1929) The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol 68(3) 213—237 Englert M, Quitterer U, Klotz K-N (2002) Effector coupling of stably transfected human A3 adenosine receptors in CHO cells. Biochem Pharmacol 64(l) 69-73 Fossetta J, Jackson J, Deno G, Fan X, Du XK, Bober L, Soude-Bermejo A, de Bouteiller O, Caux C, Lunn C, Lundell D, Palmer RK (2003) Pharmacological analysis of calcium responses mediated by the human A, adenosine receptor in monocyte-derived dendritic cells and recombinant cells. Mol Pharmacol 63(2) 342-350... 

Drury AN, Szent-Gyorgyi A (1929) The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol 68(3) 213-237 Duncker DJ, Bache RJ (2008) Regulation of coronary blood flow during exercise. Physiol Rev 88(3) 1009-1086... 

Cytokinins are unique among plant hormones in that adenine compounds of identical structure occur in nucleic acids. More specifically, particular cytokinin-active ribonucleosides occur as components of certain molecular species of tRNA. Zachau et al. (19), during the determination of the base sequences of serine tRNA in yeast, first reported an "odd" base immediately adjacent to the 3 end of the anticodon. In collaboration with Biemann et al. (20), this "odd" base was identified as the natural cytokinin isopentenyl-adenosine, which is one of the most highly active cytokinins known. 

F.Dh. Adenine compounds Total oxypurines Adenine % total... 

Total oxypurines Adenine compounds + hypoxanthine + xanthine + uric acid... 

GMP reductase (EC 1.6.6.8) a flavin enzyme which catalyses the conversion of guanosine S -monophosphate to inosinic acid in a sin e step. It is part of the system for converting guanine to adenine compounds. 

Hypoxanthine, Hyp 6-hydroxypurine, a widely distributed purine derivative in plants and animals (formula, see Inosine), M, 136.11, m.p. 150 C (d.). It is produced during aerobic Purine catabolism (see) by deamination of adenine compounds or by hydrolysis of inosine compounds. It is found as a rare base in certain transfer RNAs. 

J.F. Kuttesch, F.C. Schmalstieg, and J.A. Nelson, Analysis of adenosine and other adenine compounds in patients with immunodeficiency diseases, J. Liquid Chromatogr. 1 97 (1978). 

The effect of other adenine compounds on platelets and their metabolic interconversions have been reportedf ... 

Assay procedures for ATP depend in general on the unique physical and chemical, including enzymic, properties of this class of compound. Among these properties are the absorption spectrum of the purine component, the insolubility of adenine compounds or of phosphate salts, the acid lability of the pyrophosphate linkage, the net charge dependent on the pA value and number of acid groups, and the specificity of ATP in various enzymic reactions. 

Amethopterin treatment not only increased formate incorporation into liver acid-soluble adenine compounds but also increased the incorporation of formate into nucleic acid and protein 202). It has been foimd that incorporation of formate-C into liver proteins and nucleic acids is also stimu-... 

The mutant strain (S0 405) lacks the enzyme adenylosuccinate lyase, required for novo purine biosynthesis as well as for the conversion of s-AMP to AMP. This strain therefore has a specific requirement for an adenine compound and a general purine requirement. As the strain lacks nucleoside phosphorylase and adenosine deaminase the pathways for nucleoside utilization via free bases are ruled out. 

FIGURE 9. Representation of the hydrogen bonding interactions between the exo-cyclic amino group and the neighboring chain in the purine/adenine compound. 

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